Journal article
Intestinal pseudo-obstruction in systemic lupus erythematosus: an analysis of nationwide inpatient sample
Clinical rheumatology, Vol.41(11), pp.3331-3335
11/01/2022
DOI: 10.1007/s10067-022-06283-z
PMID: 35819642
Abstract
Intestinal pseudo-obstruction (IPO) is a rare gastrointestinal complication of systemic lupus erythematosus (SLE). We aimed to determine the prevalence and in-hospital outcomes of SLE-related intestinal pseudo-obstruction (SLE-IPO) using a large national database. This is a retrospective study using Nationwide Inpatient Sample (NIS) from 2016 to 2018. We included adult patients with SLE using International Classification of Diseases 10th Revision (ICD-10) code M32 in combination with codes for IPO, and we determined the in-hospital mortality, occurrence of sepsis, length of hospitalization, use of total parenteral nutrition (TPN), and frequency of surgical gastrointestinal procedures. The prevalence of IPO among hospitalized adult SLE patients was 1.7%, and the in-hospital mortality of SLE-IPO was 5.04%. Compared with SLE patients without IPO (group 2), SLE-IPO patients had higher in-hospital mortality (OR 2.07, 95%CI 1.60-2.64), higher risk of sepsis (OR 1.63, 95%CI 1.42-1.87), longer in-hospital stay (p 3.09, 95%CI 2.76-3.42), and higher frequency of TPN (OR 16.20, 95%CI 11.62-22.21) and gastrointestinal procedures (OR 5.47, 95%CI 4.62-6.43). SLE-IPO was associated with increased risk of sepsis (OR 1.29, 95%CI 1.12-1.49), compared with idiopathic IPO patients (group 3), and a possible increase in the frequency of gastrointestinal procedures (OR 1.14, 95%CI 0.96-1.34) compared with IPO secondary to diabetes mellitus (group 4), although not statistically significant. SLE-IPO patients were at twofold risk of in-hospital mortality compared with SLE patients without IPO. SLE-IPO was also associated with longer in-hospital stay and increased frequency of TPN and gastrointestinal procedures.
Details
- Title: Subtitle
- Intestinal pseudo-obstruction in systemic lupus erythematosus: an analysis of nationwide inpatient sample
- Creators
- Jiayi Zheng - The Wright Center for Graduate Medical EducationRuoning Ni - University of IowaHongli Liu - Rochester General Hospital
- Resource Type
- Journal article
- Publication Details
- Clinical rheumatology, Vol.41(11), pp.3331-3335
- DOI
- 10.1007/s10067-022-06283-z
- PMID
- 35819642
- NLM abbreviation
- Clin Rheumatol
- ISSN
- 0770-3198
- eISSN
- 1434-9949
- Publisher
- Springer Nature
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984946627502771
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