Journal article
Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid
Depression and anxiety, Vol.10(2), pp.77-80
1999
DOI: 10.1002/(SICI)1520-6394(1999)10:2<77::AID-DA7>3.0.CO;2-W
PMID: 10569131
Abstract
Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the rat central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lacking. A post hoc analysis of serial concentrations of immunoreactive CCK and CRH, obtained every ten minutes from CSF continuously collected over six hours, was performed. A total of 30 subjects were studied: 15 normal volunteers, 10 patients with major depression, and 5 recently-abstinent, alcohol-dependent patients. Overall, we observed an average intra-subject correlation of +.273 (P < 0.001) between CSF CRH and CCK. Inter-subject correlations between mean CSF levels of CRH and CCK were +.948 (P = 0.0001) and +.959 (P = 0.005) in the depressed and abstinent alcoholic patients, respectively. These inter-individual correlations were significantly greater than that seen within the group of normal volunteers (r = +.318, n.s.). The present data suggest that interactions between CCK and CRH are significant in the human CNS, particularly perhaps in depressed and alcoholic patients, and that CSF samples may be used to assess elements of the relationship between these hormones.
Details
- Title: Subtitle
- Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid
- Creators
- Thomas D Geracioti Jr - Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, OhioNosa N. Ekhator - Veterans Health AdministrationWendell E. Nicholson - Vanderbilt University Medical CenterStephan Arndt - University of IowaPeter T. Loosen - Vanderbilt University Medical CenterDavid N. Orth - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Depression and anxiety, Vol.10(2), pp.77-80
- DOI
- 10.1002/(SICI)1520-6394(1999)10:2<77::AID-DA7>3.0.CO;2-W
- PMID
- 10569131
- ISSN
- 1091-4269
- eISSN
- 1520-6394
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 4
- Language
- English
- Date published
- 1999
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132186302771
Metrics
1 Record Views