Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid

Thomas D Geracioti Jr; Nosa N. Ekhator; Wendell E. Nicholson; Stephan Arndt; Peter T. Loosen; David N. Orth

doi:10.1002/(SICI)1520-6394(1999)10:2<77::AID-DA7>3.0.CO;2-W

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Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid

Journal article

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Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid

Thomas D Geracioti Jr, Nosa N. Ekhator, Wendell E. Nicholson, Stephan Arndt, Peter T. Loosen and David N. Orth

Depression and anxiety, Vol.10(2), pp.77-80

1999

DOI: 10.1002/(SICI)1520-6394(1999)10:2<77::AID-DA7>3.0.CO;2-W

PMID: 10569131

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Abstract

Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the rat central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lacking. A post hoc analysis of serial concentrations of immunoreactive CCK and CRH, obtained every ten minutes from CSF continuously collected over six hours, was performed. A total of 30 subjects were studied: 15 normal volunteers, 10 patients with major depression, and 5 recently-abstinent, alcohol-dependent patients. Overall, we observed an average intra-subject correlation of +.273 (P < 0.001) between CSF CRH and CCK. Inter-subject correlations between mean CSF levels of CRH and CCK were +.948 (P = 0.0001) and +.959 (P = 0.005) in the depressed and abstinent alcoholic patients, respectively. These inter-individual correlations were significantly greater than that seen within the group of normal volunteers (r = +.318, n.s.). The present data suggest that interactions between CCK and CRH are significant in the human CNS, particularly perhaps in depressed and alcoholic patients, and that CSF samples may be used to assess elements of the relationship between these hormones.

Brain

alcohol

alcohol dependence

alcoholism

anxiety

central nervous system (CNS)

cerebrospinal fluid (CSF)

cholecystokinin (CCK)

corticotropin-releasing factor (CRF)

corticotropin-releasing hormone (CRH)

depression

major depression

Details

Title: Subtitle: Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid
Creators: Thomas D Geracioti Jr - Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, Ohio
Nosa N. Ekhator - Veterans Health Administration
Wendell E. Nicholson - Vanderbilt University Medical Center
Stephan Arndt - University of Iowa
Peter T. Loosen - Vanderbilt University Medical Center
David N. Orth - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: Depression and anxiety, Vol.10(2), pp.77-80
DOI: 10.1002/(SICI)1520-6394(1999)10:2<77::AID-DA7>3.0.CO;2-W
PMID: 10569131
NLM abbreviation: Depress Anxiety
ISSN: 1091-4269
eISSN: 1520-6394
Publisher: John Wiley & Sons, Inc
Number of pages: 4
Language: English
Date published: 1999
Academic Unit: Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
Record Identifier: 9985132186302771

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