Journal article
Intra-Articular Mineralization on Knee CT and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study
Arthritis & rheumatology (Hoboken, N.J.), Vol.76(7), pp.1054-1061
02/19/2024
DOI: 10.1002/art.42832
PMCID: PMC11213667
PMID: 38369918
Abstract
Intra-articular (IA) mineralization may contribute to OA structural progression. We studied the association of IA mineralization on knee CT with cartilage damage worsening on knee MRI, with a focus on location- and tissue-specific effects.
Participants from the Multicenter Osteoarthritis study with knee CTs and MRIs were included. Presence of IA mineralization on CT was defined as a Boston University Calcium Knee Score (BUCKS) >0 anywhere in the knee. Cartilage worsening on MRI was defined as any increase in MRI OA Knee Score (MOAKS) including incident damage. We evaluated the association of whole-knee, compartment-specific (i.e., medial or lateral), and subregion-specific (i.e., location-matched) IA mineralization at baseline with cartilage worsening at 2-year follow-up in the corresponding locations using binomial regression with generalized estimating equations, adjusting for age, sex, and body mass index (BMI).
We included 1673 participants (mean age 60 years, 56% female, mean BMI 29 kg/m
). 9.0% had any IA mineralization in the knee and 47.4% had any cartilage worsening on follow-up. Mineralization of any tissue in the knee, regardless of location, was not associated with MRI cartilage worsening. However, cartilage mineralization was associated with 1.39 (95% CI 1.04, 1.88) times higher risk of cartilage worsening in the same compartment with similar results in subregion-specific analysis.
CT-detected IA mineralization in the cartilage was associated with higher risk of MRI cartilage worsening in the same compartment and subregion over two years. These findings suggest potential localized, tissue-specific effects of IA mineralization on cartilage pathology in knee OA.
Details
- Title: Subtitle
- Intra-Articular Mineralization on Knee CT and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study
- Creators
- Jean W Liew - Boston UniversityMohammed Jarraya - Massachusetts General HospitalAli Guermazi - Boston UniversityDavid Felson - Boston UniversityMichael Nevitt - University of California, San FranciscoCora E Lewis - University of Alabama at BirminghamJames Torner - University of IowaFrank W Roemer - Boston UniversityMichel D Crema - Institut National du Sport, de l'Expertise et de la PerformanceNa Wang - Boston UniversityGabriela Rabasa - Boston UniversityFabio Becce - University of LausanneTristan Pascart - Université Catholique de LilleTuhina Neogi - Boston University
- Resource Type
- Journal article
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), Vol.76(7), pp.1054-1061
- DOI
- 10.1002/art.42832
- PMID
- 38369918
- PMCID
- PMC11213667
- NLM abbreviation
- Arthritis Rheumatol
- eISSN
- 2326-5205
- Grant note
- DOI: 10.13039/100000002, name: NIH, award: P30‐AR‐072571, U01‐AG‐18820, U01‐AG‐18832, U01‐AG‐18947, U01‐AG‐19079, K24‐AR‐070892; DOI: 10.13039/100006260, name: RRF
- Language
- English
- Electronic publication date
- 02/19/2024
- Academic Unit
- Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984560423802771
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