Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditions

Ryan T LaLumiere; Emmanuel Pizano; James L McGaugh

doi:10.1016/S1074-7427(03)00089-3

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Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditions

Journal article

Peer reviewed

Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditions

Ryan T LaLumiere, Emmanuel Pizano and James L McGaugh

Neurobiology of learning and memory, Vol.81(1), pp.60-66

01/2004

DOI: 10.1016/S1074-7427(03)00089-3

PMID: 14670359

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Abstract

Previous evidence has suggested that N-methyl-D-aspartate receptors (NMDARs) in the basolateral amygdala (BLA) are critically involved in the acquisition of aversively based learning tasks. However, the role of NMDARs in the BLA in the consolidation of memory of aversive training has not been well elucidated. In the present study, the NMDAR antagonist AP-5 (1 or 3 microg) was infused into the BLA of male Sprague-Dawley rats immediately before, immediately after, or 6h after training on an inhibitory avoidance task with either a high footshock (HFS; only high dose of AP-5 given) or a low footshock (LFS; both doses of AP-5 given). The 48 h retention of animals given AP-5 (3 microg) immediately before or after HFS training was significantly impaired compared to that of vehicle-controls. In contrast, the retention of rats given AP-5 (3 microg) immediately after LFS training was significantly enhanced compared to that of vehicle-controls. AP-5 (3 microg) infusions administered 6h after training with either an HFS or LFS did not affect retention. These findings suggest that the NMDARs in the BLA are involved in both the acquisition and consolidation of aversive memory. In addition, the AP-5-induced enhancement of memory obtained with LFS training suggests that NMDARs in the BLA are involved in other mechanisms influencing synaptic transmission, in addition to their well-established role in neuroplasticity.

Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors

Amygdala - drug effects

Conditioning, Classical - drug effects

Retention (Psychology) - drug effects

2-Amino-5-phosphonovalerate - pharmacology

Fear - drug effects

Rats

Male

Mental Recall - drug effects

Rats, Sprague-Dawley

Association Learning - drug effects

Dose-Response Relationship, Drug

Animals

2-Amino-5-phosphonovalerate - analogs & derivatives

Brain Mapping

Avoidance Learning - drug effects

Details

Title: Subtitle: Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditions
Creators: Ryan T LaLumiere - Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA. rlalumie@uci.edu
Emmanuel Pizano
James L McGaugh
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.81(1), pp.60-66
Publisher: United States
DOI: 10.1016/S1074-7427(03)00089-3
PMID: 14670359
ISSN: 1074-7427
eISSN: 1095-9564
Grant note: MH12526 / NIMH NIH HHS
Language: English
Date published: 01/2004
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070869402771

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