Journal article
Intra-individual Variability in Prodromal Huntington Disease and Its Relationship to Genetic Burden
Journal of the International Neuropsychological Society, Vol.21(1), pp.8-21
01/2015
DOI: 10.1017/S1355617714001076
PMCID: PMC4549971
PMID: 26304055
Abstract
The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV across 15 neuropsychological tasks and within-task IIV using a self-paced timing task were compared as a single measure of processing speed (Symbol Digit Modalities Test [SDMT]) in 693 gene-expanded and 191 nongene-expanded participants from the PREDICT-HD study. After adjusting for depressive symptoms and motor functioning, individuals estimated to be closest to HD diagnosis displayed higher levels of across- and within-task variability when compared to controls and those prodromal HD participants far from disease onset (F
ICV(3,877)=11.25; p<.0001; F
PacedTiming(3,877)=22.89; p<.0001). When prodromal HD participants closest to HD diagnosis were compared to controls, Cohen’s d effect sizes were larger in magnitude for the within-task variability measure, paced timing (−1.01), and the SDMT (−0.79) and paced tapping coefficient of variation (CV) (−0.79) compared to the measures of across-task variability [CV (0.55); intra-individual standard deviation (0.26)]. Across-task variability may be a sensitive marker of cognitive decline in individuals with prodromal HD approaching disease onset. However, individual neuropsychological tasks, including a measure of within-task variability, produced larger effect sizes than an index of across-task IIV in this sample. (JINS, 2015, 21, 8–21)
Details
- Title: Subtitle
- Intra-individual Variability in Prodromal Huntington Disease and Its Relationship to Genetic Burden
- Creators
- Mandi Musso - Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode IslandHolly James Westervelt - Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode IslandJeffrey D Long - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaErin Morgan - Department of Psychiatry, University of California, San Diego, San Diego, CaliforniaSteven Paul Woods - Department of Psychiatry, University of California, San Diego, San Diego, CaliforniaMegan M Smith - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaWenjing Lu - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IowaJane S Paulsen - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaPREDICT-HD Investigators of the Huntington Study Group
- Contributors
- Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.21(1), pp.8-21
- DOI
- 10.1017/S1355617714001076
- PMID
- 26304055
- PMCID
- PMC4549971
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Publisher
- Cambridge University Press
- Number of pages
- 14
- Alternative title
- IIV in prodromal Huntington disease
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Biostatistics; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
- Record Identifier
- 9984221729302771
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