Journal article
Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients
Kidney international, Vol.78(8), pp.769-773
10/02/2010
DOI: 10.1038/ki.2010.254
PMID: 20668427
Abstract
An accurate assessment of iron status in dialysis patients is important because both anemia and overtreatment with erythropoiesis-stimulating agents are associated with poor clinical outcomes. We have previously shown that both analytical and intra-individual (biological) variability in serum ferritin limits its utility as a proxy for iron stores in patients in this setting. As hepcidin is a direct regulator of iron status, its measurement might be useful for monitoring patients with iron dysregulation. We assessed short-term intra-individual variation of serum hepcidin in 28 patients with stable chronic kidney disease on hemodialysis. The intra-individual variability for serum hepcidin ranged from 9–79% during an initial 2-week to 12–85% over a 6-week period. The concentration of serum hepcidin was significantly correlated with serum C-reactive protein levels over the 6-week study period. Hence, significant intra-individual variability of hepcidin is likely dependent on short-term fluctuations in the inflammatory state. Thus, our results suggest that short-term measurement of serum hepcidin should not be used to guide clinical decisions regarding management of iron status in chronic hemodialysis patients.
Details
- Title: Subtitle
- Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients
- Creators
- Bradley A Ford - Departments of Pathology and Immunology, Washington University, St Louis, Missouri, USACharles S Eby - Departments of Pathology and Immunology, Washington University, St Louis, Missouri, USAMitchell G Scott - Departments of Pathology and Immunology, Washington University, St Louis, Missouri, USADaniel W Coyne - Department of Medicine, Washington University, St Louis, Missouri, USA
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.78(8), pp.769-773
- DOI
- 10.1038/ki.2010.254
- PMID
- 20668427
- NLM abbreviation
- Kidney Int
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 10/02/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984047992302771
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