Journal article
Intra-operative frozen section results reliably predict final pathology in endometrial cancer
Gynecologic Oncology, Vol.133(3), pp.499-505
06/2014
DOI: 10.1016/j.ygyno.2014.03.569
PMID: 24699308
Abstract
Typically, complete surgical staging is necessary for patients with high-risk endometrial cancer. However, patients with low-risk disease may be able to avoid lymphadenectomy and its associated morbidity. We sought to evaluate the agreement rates between the intra-operative frozen sections (FSs) and the final paraffin sections (PSs) at our institution, and to determine if this was a reliable method for guiding our intra-operative decision-making with regard to the necessity of lymphadenectomy. 116 patients with a pre-operative diagnosis of endometrioid adenocarcinoma of the uterus or complex atypical hyperplasia (CAH) underwent surgery at our institution. Demographic data, as well as information on stage, grade, histology and depth of invasion determined at FS and on PS were collected. Cohen's kappa statistic was used to assess the agreement rate between FS and final PS with regard to depth of invasion, grade, and histology. Our correlation rate between FS and final PS for histologic subtype, grade, and depth of myometrial invasion was 97.5%, 88%, and 98.2% respectively. Seven cases identified as complex atypical hyperplasia on FS were later determined to be cancerous on final PS, resulting in two patients being undertreated. Our results support the use of FS analysis as a means to guide intra-operative decisions regarding lymphadenectomy. Determination of histologic subtype, depth of invasion and grade is reliable at our institution, and demonstrates high concordance rates between FS and PS. These factors should be used to guide intra-operative decision-making regarding the necessity of a lymphadenectomy in patients with endometrial cancer. •Correlation between frozen section and paraffin section for histology, grade, and depth of invasion was 97.5%, 88%, and 98.2% respectively.•Our results support frozen section analysis as a means to guide intra-operative decision-making regarding the necessity of a lymphadenectomy.•Frozen section is a reasonable alternative to the “all or none” approach regarding lymphadenectomy for low-risk endometrial cancer patients.
Details
- Title: Subtitle
- Intra-operative frozen section results reliably predict final pathology in endometrial cancer
- Creators
- Jean-Marie Stephan - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAJean Hansen - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMegan Samuelson - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMegan McDonald - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAYenna Chin - University of IowaDavid Bender - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAHenry D Reyes - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAAnna Button - Department of Biostatistics, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMichael J Goodheart - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Gynecologic Oncology, Vol.133(3), pp.499-505
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.ygyno.2014.03.569
- PMID
- 24699308
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Pathology; Obstetrics and Gynecology
- Record Identifier
- 9983931824102771
Metrics
17 Record Views