Journal article
Intracellular delivery of RNA-based therapeutics using aptamers
Therapeutic delivery, Vol.1(6), pp.849-861
12/01/2010
DOI: 10.4155/TDE.10.61
PMCID: PMC3106310
PMID: 21643487
Abstract
The clinical potential of siRNAs for silencing genes critical to disease progression is clear, but a fail-proof method for delivering siRNAs to the cytoplasm of diseased tissues or cells has yet to be identified. A variety of delivery approaches have been explored to directly or indirectly couple siRNAs to delivery vehicles. This review explores the use of synthetic single-stranded DNA and RNA aptamers as a means to deliver siRNAs, shRNAs and antisense oligonucleotides for therapeutic intervention. Topics covered include: the advantages and challenges of using aptamers as delivery tools; current aptamer-mediated siRNA delivery platforms for the treatment of cancer and HIV; and emerging methodologies for the identification of aptamers capable of internalizing into target cell types.
Details
- Title: Subtitle
- Intracellular delivery of RNA-based therapeutics using aptamers
- Creators
- Kristina W. Thiel - University of IowaPaloma H. Giangrande - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Therapeutic delivery, Vol.1(6), pp.849-861
- DOI
- 10.4155/TDE.10.61
- PMID
- 21643487
- PMCID
- PMC3106310
- NLM abbreviation
- Ther Deliv
- ISSN
- 2041-5990
- eISSN
- 2041-6008
- Publisher
- Future Sci Ltd
- Number of pages
- 13
- Grant note
- R01CA138503 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32HL007344 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 1RO1 CA138503-01A1; 1R21DE019953-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MKACF 001-09 / Mary Kay Ash Foundation R21DE019953 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) Ladies Auxiliary to the Veterans of Foreign Wars Postdoctoral Fellowship
- Language
- English
- Date published
- 12/01/2010
- Academic Unit
- Radiation Oncology; Obstetrics and Gynecology; Internal Medicine
- Record Identifier
- 9984383299602771
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