Journal article
Intracellular trafficking of adeno-associated viral vectors
Gene therapy, Vol.12(11), pp.873-880
06/2005
DOI: 10.1038/sj.gt.3302527
PMID: 15829993
Abstract
Adeno-associated virus (AAV) has attracted considerable interest as a gene therapy vector over the past decade. In all, 85% of the current 2052 PubMed references on AAV (as of December 2004) have been published in the last 10 years. As researchers have moved forward with using this vector system for gene delivery, an increased appreciation for the complexities of AAV biology has emerged. The biology of recombinant AAV (rAAV) transduction has demonstrated considerable diversity in different cell types and target tissues. This review will summarize the current understanding of events that control rAAV transduction following receptor binding and leading to nuclear uptake. These stages are broadly classified as intracellular trafficking and have been found to be a major rate-limiting step in rAAV transduction for many cell types. Advances in understanding this area of rAAV biology will help to improve the efficacy of this vector system for the treatment of inherited and acquired diseases.
Details
- Title: Subtitle
- Intracellular trafficking of adeno-associated viral vectors
- Creators
- W Ding - Department of Anatomy and Cell Biology, University of Iowa School of Medicine, Iowa City, 52242, USAL ZhangZ YanJ F Engelhardt
- Resource Type
- Journal article
- Publication Details
- Gene therapy, Vol.12(11), pp.873-880
- DOI
- 10.1038/sj.gt.3302527
- PMID
- 15829993
- NLM abbreviation
- Gene Ther
- ISSN
- 0969-7128
- eISSN
- 1476-5462
- Publisher
- England
- Grant note
- R01 HL58340 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025358202771
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