Journal article
Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning
Behavioural brain research, Vol.378, pp.112258-112258
01/27/2020
DOI: 10.1016/j.bbr.2019.112258
PMCID: PMC6930804
PMID: 31560921
Abstract
Intracerebellar administration of cannabinoid agonists impairs cerebellum-dependent delay eyeblink conditioning (EBC) in rats. It is not known whether the cannabinoid-induced impairment in EBC is found with shorter interstimulus intervals (ISI), longer ISIs, or with trace EBC. Moreover, systemic administration of cannabinoid agonists does not impair trace EBC, suggesting that cannabinoid receptors within the cerebellum are not involved in trace EBC. To more precisely assess the effects of cannabinoids on cerebellar learning mechanisms the current study examined the effects of the cannabinoid agonist WIN55,212-2 (WIN) infusion into the area of the cerebellar cortex necessary for EBC (the eyeblink microzone) in rats during short delay (250 ms CS), long delay (750 ms CS), and trace (250 ms CS, 500 ms trace interval) EBC. WIN was infused into the eyeblink microzone 30 min before pretraining sessions and five EBC training sessions, followed by five EBC training sessions without infusions to assess recovery from drug effects and savings. WIN had no effect on spontaneous blinks or non-associative responses to the CS or US during the pretraining sessions. Short and long delay EBC were impaired by WIN but trace EBC was unaffected. The results indicate that trace EBC is mediated by mechanisms that are resistant to cannabinoid agonists.
Details
- Title: Subtitle
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning
- Creators
- Adam B Steinmetz - Department of Psychological and Brain Sciences, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USAJohn H Freeman - Department of Psychological and Brain Sciences, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA. Electronic address: john-freeman@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.378, pp.112258-112258
- DOI
- 10.1016/j.bbr.2019.112258
- PMID
- 31560921
- PMCID
- PMC6930804
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Netherlands
- Grant note
- R01 MH080005 / NIMH NIH HHS R01 NS088567 / NINDS NIH HHS
- Language
- English
- Date published
- 01/27/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065754602771
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