Intracerebral hemorrhage after IV tPA for stroke as early symptom of ANCA-associated vasculitis

Neda Zarghami Esfahani; Daniel M Anderson; Connie Pieper; Harold P Adams Jr

doi:10.1016/j.ensci.2017.08.004

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Intracerebral hemorrhage after IV tPA for stroke as early symptom of ANCA-associated vasculitis

Journal article

Open access

Peer reviewed

Intracerebral hemorrhage after IV tPA for stroke as early symptom of ANCA-associated vasculitis

Neda Zarghami Esfahani, Daniel M Anderson, Connie Pieper and Harold P Adams Jr

eNeurologicalSci, Vol.9, pp.1-2

09/01/2017

DOI: 10.1016/j.ensci.2017.08.004

PMID: 29260039

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Published (Version of record)eNeurologicalSci 9 (December 2017) Pages 1-2

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare diseases characterized by a necrotizing small-vessel vasculitis and circulating ANCA that comprise granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (EGPA). Acute ischemic stroke (AIS) can be a manifestation of central nervous system (CNS) involvement in these diseases. Furthermore, intracerebral hemorrhage (ICH) is a potential complication of these necrotizing vasculitides. We describe a case of AAV who presented with acute ischemic stroke and developed multiple ICHs after administration of IV tPA. We propose that patients with AAV are more prone to develop hemorrhage in the presence of IV tPA and discuss the possible underlying pathogenesis. We suggest that AAV should be considered a contraindication for administration of IV tPA.

Neurology

Nervous System Diseases

OAfund

ANCA associated vasculitis

Intracerebral hemorrhage

Ischemic stroke

IV tPA

Details

Title: Subtitle: Intracerebral hemorrhage after IV tPA for stroke as early symptom of ANCA-associated vasculitis
Creators: Neda Zarghami Esfahani - University of Iowa
Daniel M Anderson - University of Iowa
Connie Pieper - University of Iowa
Harold P Adams Jr - University of Iowa
Resource Type: Journal article
Publication Details: eNeurologicalSci, Vol.9, pp.1-2
DOI: 10.1016/j.ensci.2017.08.004
PMID: 29260039
ISSN: 2405-6502
Grant note: DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 09/01/2017
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9983557222202771

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