Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity

Martin S Muntzel; Donald A Morgan; Allyn L Mark; Alan Kim Johnson

doi:10.1152/ajpregu.1994.267.5.r1350

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Journal article

Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity

Martin S Muntzel, Donald A Morgan, Allyn L Mark and Alan Kim Johnson

American journal of physiology. Regulatory, integrative, and comparative physiology, Vol.267(5 Pt 2), pp.R1350-1355

11/1994

DOI: 10.1152/ajpregu.1994.267.5.r1350

PMID: 7977864

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Abstract

Insulin has been shown to increase sympathetic nerve activity (SNA). Although it has been proposed that insulin acts within the central nervous system (CNS) to increase sympathetic neural outflow, there is little evidence for direct central neural sympathoexcitatory effects of insulin. To determine whether intracerebroventricular insulin elicits increases in peripheral SNA, we infused insulin (0.1 microU/min, low; 10 microU/min, medium; and 100 microU/min, high doses) or artificial cerebrospinal fluid (aCSF) into the third cerebral ventricle of chloralose-anesthetized Wistar rats while recording lumbar SNA. In separate animals, 10 microU/min of insulin were infused while recording adrenal SNA and renal SNA. Blood glucose and plasma insulin levels did not significantly change during intracerebroventricular infusion of insulin. Lumbar SNA, expressed as percentage of baseline, did not change in rats infused with aCSF (+ 13% +/- 8%) but increased significantly in rats infused with low (+ 72 +/- 17%), medium (+ 119 +/- 30%), and high (+ 113 +/- 25%) doses of insulin (P < 0.05). Intracerebroventricular insulin failed to significantly increase adrenal SNA or renal SNA. Blood pressure and heart rate did not change during insulin infusion. The results indicate that administration of insulin into the third cerebral ventricle produces regionally nonuniform increases in sympathetic neural outflow in the absence of changes in blood glucose or plasma insulin.

Adrenal Glands - innervation

Animals

Blood Glucose - metabolism

Blood Pressure - drug effects

Carbachol - pharmacology

Cerebral Ventricles - drug effects

Cerebral Ventricles - physiology

Dose-Response Relationship, Drug

Heart Rate - drug effects

Infusions, Parenteral

Insulin - administration & dosage

Insulin - pharmacology

Kidney - innervation

Male

Rats

Rats, Wistar

Reference Values

Sympathetic Nervous System - drug effects

Sympathetic Nervous System - physiology

Time Factors

Details

Title: Subtitle: Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity
Creators: Martin S Muntzel - Department of Psychology, University of Iowa, Iowa City
Donald A Morgan
Allyn L Mark
Alan Kim Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative, and comparative physiology, Vol.267(5 Pt 2), pp.R1350-1355
DOI: 10.1152/ajpregu.1994.267.5.r1350
PMID: 7977864
ISSN: 0363-6119
eISSN: 1522-1490
Grant note: HL-14338 / NHLBI NIH HHS HL-08704 / NHLBI NIH HHS HL-44546 / NHLBI NIH HHS
Language: English
Date published: 11/1994
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
Record Identifier: 9984213269302771

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