Journal article
Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials
Laryngoscope investigative otolaryngology, Vol.4(6), pp.678-683
12/2019
DOI: 10.1002/lio2.329
PMCID: PMC6929576
PMID: 31890888
Abstract
Objective
To report current knowledge on the topic of intracochlear fibrosis and the foreign body response following cochlear implantation (CI).
Methods
A literature search was performed in PubMed to identify peer‐reviewed articles. Search components included “cochlear implant,” “Foreign body response (FBR),” and “fibrosis.” Original studies and review articles relevant to the topic were included.
Results
Ninety peer‐reviewed articles describing the foreign body response or intracochlear fibrosis following CI were included.
Conclusions
Intracochlear fibrosis following CI represents a significant limiting factor for the success of CI users. Several strategies have been employed to mitigate the foreign body response within the cochlea including drug delivery systems and modifications in surgical technique and electrode design. A better understanding of the FBR has the potential to improve CI outcomes and the next generation of cochlear prostheses.
Intracochlear fibrosis following CI represents a significant limiting factor for the success of CI users. Several strategies have been employed to mitigate the foreign body response within the cochlea including drug delivery systems and modifications in surgical technique and electrode design. A better understanding of the FBR has the potential to improve CI outcomes and the next generation of cochlear prostheses.
Details
- Title: Subtitle
- Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials
- Creators
- Megan J. Foggia - University of Iowa Hospitals and ClinicsRene Vielman Quevedo - University of IowaMarlan R. Hansen - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Laryngoscope investigative otolaryngology, Vol.4(6), pp.678-683
- DOI
- 10.1002/lio2.329
- PMID
- 31890888
- PMCID
- PMC6929576
- NLM abbreviation
- Laryngoscope Investig Otolaryngol
- ISSN
- 2378-8038
- eISSN
- 2378-8038
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 6
- Grant note
- National Institute on Deafness and Other Communication Disorders (R01 DC012578; 5T32DC000040; P50 DC00242)
- Language
- English
- Date published
- 12/2019
- Academic Unit
- Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984297602102771
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