Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage

D W Nibbelink; J C Torner; W G Henderson

doi:10.1161/01.STR.6.6.622

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Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage

Journal article

Open access

Peer reviewed

Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage

D W Nibbelink, J C Torner and W G Henderson

Stroke (1970), Vol.6(6), pp.622-629

11/1975

DOI: 10.1161/01.STR.6.6.622

PMID: 1198627

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Abstract

In this cooperative study among 13 institutions, 502 patients were treated with antifibrinolytic medication (epsilon-aminocaproic acid or tranexamic acid) within a 14-day period following rupture of an intracranial aneurysm. Mortality at the end of 14 days was 11.6%; proved rebleed rate was 12.7%. Patients with an internal carotid or anterior cerebral aneurysm had the highest mortality and rebleed rate. Most rebleeds occurred between the sixth and eleventh days following the initial bleed. Significantly higher mortality was reported among patients with cerebral vasospasm, yet rebleed rate was no different among those patients with or without vasospasm. The same pattern was observed among patients with a mean blood pressure value above and below 110 mm Hg. We conclude that antifibrinolytic therapy provides beneficial treatment to patients with recent onset subarachnoid hemorrhage (SAH) following rupture of an intracranial aneurysm.

Antifibrinolytic Agents - therapeutic use

Ischemic Attack, Transient - drug therapy

Age Factors

Humans

Middle Aged

Intracranial Aneurysm - mortality

Male

Intracranial Aneurysm - complications

Secondary Prevention

Tranexamic Acid - therapeutic use

Tranexamic Acid - adverse effects

Sex Factors

Subarachnoid Hemorrhage - etiology

Subarachnoid Hemorrhage - mortality

Female

Aminocaproates - therapeutic use

Intracranial Aneurysm - drug therapy

Rupture, Spontaneous

Subarachnoid Hemorrhage - drug therapy

Aminocaproates - adverse effects

Details

Title: Subtitle: Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage
Creators: D W Nibbelink
J C Torner
W G Henderson
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.6(6), pp.622-629
DOI: 10.1161/01.STR.6.6.622
PMID: 1198627
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: United States
Language: English
Date published: 11/1975
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995111302771

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