Journal article
Intracranial blood flow velocity in patients with β -thalassemia intermedia using transcranial doppler sonography: A case-control study
Anemia, Vol.2012(2012), pp.295-298
01/01/2012
DOI: 10.1155/2012/798296
PMCID: PMC3254003
PMID: 22263107
Abstract
Introduction. Patients with β-thalassemia intermedia have a higher incidence of thromboembolic events compared to the general population. Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have higher intracranial arterial blood flow velocities measured by transcranial Doppler sonography (TCD). The aim of this study is to evaluate intracranial arterial flow velocities in patients with β-thalassemia intermedia and compare the results with those found in healthy subjects. Methods. Sixty-four patients with β-thalassemia intermedia and 30 healthy subjects underwent transcranial Doppler sonography. Results. Significantly higher flow velocities were found in intracranial arteries of patients compared to controls (P = 0.001). Previously splenectomized patients with thrombocytosis showed higher flow velocities than nonsplenectomized patients without thrombosis. Conclusion. The increased flow velocities in patients with β-thalassemia intermedia may point to a higher risk of ischemic events. Preventive measures such as blood transfusion or antiplatelet treatment may be beneficial in these patients.
Details
- Title: Subtitle
- Intracranial blood flow velocity in patients with β -thalassemia intermedia using transcranial doppler sonography: A case-control study
- Creators
- Nahid Ashjazadeh - Shiraz University of Medical SciencesSajad Emami - Shiraz University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesEhsan Yaghoubi - Shiraz University of Medical SciencesMehran Karimi - Shiraz University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Anemia, Vol.2012(2012), pp.295-298
- DOI
- 10.1155/2012/798296
- PMID
- 22263107
- PMCID
- PMC3254003
- NLM abbreviation
- Anemia
- ISSN
- 2090-1267
- eISSN
- 2090-1275
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Neurology
- Record Identifier
- 9985013728802771
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