Intradiscal drug delivery system for the treatment of low back pain

Jin Whan Lee; Tae-Hong Lim; Joon B Park

doi:10.1002/jbm.a.32377

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Journal article

Peer reviewed

Intradiscal drug delivery system for the treatment of low back pain

Jin Whan Lee, Tae-Hong Lim and Joon B Park

Journal of biomedical materials research. Part A, Vol.92(1), pp.378-385

01/2010

DOI: 10.1002/jbm.a.32377

PMID: 19191317

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Abstract

Possible solution to the long-term control of the low back pain (LBP) would be by using an injectable pain drug carrier that can be delivered locally. The drug can be released in a controlled manner. It is also allowed to inject repeatedly more drugs percutaneously with a minimal invasion. The main objective of this study was to develop such a drug delivery system (DDS) for long-term control of discogenic LBP. The DDS consists of in situ forming hydrogel matrix (Pluronic F127 plus sodium hyaluronate) containing microspheres (MS). The solid MS were used for long-term release of the drugs. Both hydrogel matrix and MS contained a model drug, bupivacaine base (BB). The phase transition (liquid at room temperature, gel at around body temperature) could be manipulated by changing the composition of the hydrogel. In vitro test showed that approximately 3% (w/w) of the BB loaded to MS were released during 42 days, demonstrating a good potential for sustained release of bupivacaine.

Injections, Spinal

Bupivacaine - therapeutic use

Microscopy, Electron, Scanning

Temperature

Molecular Weight

Lumbar Vertebrae - diagnostic imaging

Solvents - chemistry

Bupivacaine - administration & dosage

Hyaluronic Acid - pharmacology

Lumbar Vertebrae - drug effects

Viscosity - drug effects

Low Back Pain - drug therapy

Radiography

Microspheres

Animals

Poloxamer - pharmacology

Bupivacaine - pharmacology

Cattle

Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology

Drug Delivery Systems - methods

Details

Title: Subtitle: Intradiscal drug delivery system for the treatment of low back pain
Creators: Jin Whan Lee - Bisco Inc, 1100 W Irving Park Rd., Schaumburg, Illinois 60193, USA
Tae-Hong Lim
Joon B Park
Resource Type: Journal article
Publication Details: Journal of biomedical materials research. Part A, Vol.92(1), pp.378-385
Publisher: United States
DOI: 10.1002/jbm.a.32377
PMID: 19191317
ISSN: 1549-3296
eISSN: 1552-4965
Language: English
Date published: 01/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984064255402771

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