Journal article
Intraductal breast carcinoma: Initial results of a morphometric study using computerized digital image analysis
Clinical oncology (Royal College of Radiologists (Great Britain)), Vol.2(2), pp.66-70
1990
DOI: 10.1016/S0936-6555(05)80789-7
PMID: 2175642
Abstract
Extensive ductal carcinoma
in situ (DCIS) and necrosis in breast carcinoma have been correlated with a higher incidence of local recurrence in patients treated with breast-conserving surgery and radiotherapy. In an attempt quantitatively to assess duct size distribution and necrosis in DCIS, the authors devised a method utilizing computerized digital image analysis. The method and results of a pilot study comparing 21 patients with DCIS, and 21 normal breast specimens are presented. Normal breast tissue from autopsy material revealed a mean duct diameter of 90 μm, whereas the mean diameter of ducts in patients with DCIS was 359 μm (
P < 0.001). The presence of necrosis in DCIS correlated strongly with average duct size. Of the ducts larger than 360 μm in diameter 94% exhibited intraductal necrosis, whereas ducts less than 360 μm showed necrosis in only 30% of the measurements. Ducts with necrosis revealed a mean diameter of 498 μm versus 198 μm in ducts without necrosis (
P < 0.001). The authors suggest that necrosis develops in response to tumour cell hypoxia associated with cross-sectional duct expansion in DCIS. This growth pattern predisposing to tumour cell hypoxia could be a factor contributing to radioresistance and increased local recurrence.
Details
- Title: Subtitle
- Intraductal breast carcinoma: Initial results of a morphometric study using computerized digital image analysis
- Creators
- N.A Mayr - University of IowaJ.J Staples - University of IowaR.A Robinson - University of IowaJ.E VanMetre - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical oncology (Royal College of Radiologists (Great Britain)), Vol.2(2), pp.66-70
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0936-6555(05)80789-7
- PMID
- 2175642
- ISSN
- 0936-6555
- eISSN
- 1433-2981
- Language
- English
- Date published
- 1990
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology
- Record Identifier
- 9984186496402771
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