Journal article
Intragenic mutations of the p16 super(INK4), p15 super(INK4B) and p18 genes in primary non-small-cell lung cancers
International journal of cancer, Vol.65(6), pp.734-739
03/01/1996
DOI: 10.1002/(SICI)1097-0215(19960315)65:6<734::AID-IJC4>3.0.CO;2-%23
Abstract
The p15 super(INK4B), p16 super(INK4) and p18 genes are members of the gene family coding for inhibitors of cyclin-dependent kinases 4 and 6. p15 super(INK4B) and p 16 super(INK4) are located at 9p21, a chromosomal region frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformation polymorphism and DNA sequencing in 71 non-small-cell lung cancer (NSCLC) samples. Six somatic mutations in the p16 super(INK4) gene and 3 cases with a polymorphic allele were observed. Loss of heterozygosity in the p18 gene was found in 1 sample. We did not find any intragenic mutations in the p15 super(INK4B) or p18 genes. We conclude that p16 super(INK4) mutations play a role in the formation of some NSCLCs, whereas the involvement of p15 super(INK4B) and p18 is uncommon.
Details
- Title: Subtitle
- Intragenic mutations of the p16 super(INK4), p15 super(INK4B) and p18 genes in primary non-small-cell lung cancers
- Creators
- M R RusinA OkamotoM ChorazyK CzyzewskiJ HarasimE A SpillareK HagiwaraS P HussainYue XiongD J DemetrickC C Harris
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.65(6), pp.734-739
- DOI
- 10.1002/(SICI)1097-0215(19960315)65:6<734::AID-IJC4>3.0.CO;2-%23
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Language
- English
- Date published
- 03/01/1996
- Academic Unit
- Public Health Administration; Epidemiology
- Record Identifier
- 9984214707302771
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