Journal article
Intrahepatic Cholangiocarcinoma
Surgical oncology clinics of North America, Vol.28(4), pp.587-599
10/2019
DOI: 10.1016/j.soc.2019.06.002
PMID: 31472907
Abstract
Intrahepatic cholangiocarcinoma (ICC) arises from the epithelial cells of the intrahepatic and extrahepatic bile ducts and occurs proximal to the segmental biliary ducts. Risk factors include chronic hepatitis and cirrhosis, biliary inflammatory diseases, and hepatobiliary flukes, although in most cases, no known risk factor is identified. ICC is highly aggressive, with long-term survival only observed in patients with a complete R0 surgical resection. Technical and physiologic resectability should be considered when performing an operative plan. Nodal involvement is among the most important prognostic factors associated with survival and a porta hepatis lymphadenectomy should be performed at the time of resection. Adjuvant chemotherapy can provide a significant survival benefit for patients with more advanced or aggressive tumors. Systemic, locoregional, and targeted therapies exist for patients with unresectable or metastatic disease.
Details
- Title: Subtitle
- Intrahepatic Cholangiocarcinoma
- Creators
- Ramy El-Diwany - Johns Hopkins UniversityTimothy M. Pawlik - The Ohio State UniversityAslam Ejaz - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Surgical oncology clinics of North America, Vol.28(4), pp.587-599
- DOI
- 10.1016/j.soc.2019.06.002
- PMID
- 31472907
- NLM abbreviation
- Surg Oncol Clin N Am
- ISSN
- 1055-3207
- eISSN
- 1558-5042
- Publisher
- Elsevier Inc
- Number of pages
- 13
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Surgery
- Record Identifier
- 9984966748902771
Metrics
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