Journal article
Intraindividual Crossover Comparison of Gadoxetic Acid Dose for Liver MRI in Normal Volunteers
Magnetic resonance in medical sciences, Vol.15(1), pp.60-72
01/01/2016
DOI: 10.2463/mrms.2015-0005
PMID: 26104082
Abstract
Purpose: We performed a quantitative intraindividual comparison of the performance of 0.025- and 0.05-mmol/kg doses for gadoxetic acid-enhanced liver magnetic resonance (MR) imaging.
Materials and Methods: Eleven healthy volunteers underwent liver MR imaging twice, once with a 0.025- and once with a 0.05-mmol/kg dose of gadoxetic acid. MR spectroscopy and 3-dimensional gradient-echo T-1-weighted images (3D-GRE) were obtained before and 3, 10, and 20 mm after injection of the contrast medium to measure T-1 and T-2 values and signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) performance. During the dynamic phase, highly time-resolved 3D-GRE was used to estimate the relative CNR (CNRrel) of the hepatic artery and portal vein (PV) to the liver. We used paired t-tests to compare the results of different doses.
Results: During the hepatobiliary phase, we observed shorter T-1 values and higher SNRs of the liver (P < 0.001) and higher liver-to-PV and liver-to-muscle CNRs (P < 0.002) using 0.05 mmol/kg compared to 0.025 mmol/kg. Increasing the dose to 0.05 mmol/kg yielded a greater T-1-shortening effect at 10 mm delay even compared with 0.025 mmol/kg at 20 mm (P < 0.001). During the dynamic phase, the peak CNRrel for the hepatic artery and portal vein were higher using 0.05 mmol/kg (P = 0.007 to 0.035).
Conclusion: Use of gadoxetic acid at a dose of 0.05 mmol/kg leads to significantly higher SNR and CNR performance than with 0.025 mmol/kg. Quantitatively, a 10-min delay may be feasible for hepatobiliary-phase imaging when using 0.05 mmol/kg of gadoxetic acid.
Details
- Title: Subtitle
- Intraindividual Crossover Comparison of Gadoxetic Acid Dose for Liver MRI in Normal Volunteers
- Creators
- Utaroh Motosugi - University of Wisconsin–MadisonPeter Bannas - University of Wisconsin–MadisonDiego Hernando - University of Wisconsin–MadisonMandi Salmani Rahimi - Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USAJames H. Holmes - General Electric (United States)Scott B. Reeder - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medical sciences, Vol.15(1), pp.60-72
- DOI
- 10.2463/mrms.2015-0005
- PMID
- 26104082
- NLM abbreviation
- Magn Reson Med Sci
- ISSN
- 1347-3182
- eISSN
- 1880-2206
- Publisher
- Jpn Soc Magnetic Resonance Medicine
- Number of pages
- 13
- Grant note
- Department of Radiology of the University of Wisconsin GE Healthcare; General Electric
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984294926802771
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