Journal article
Intralesional Injection of Mitomycin C at Transurethral Incision of Bladder Neck Contracture May Offer Limited Benefit: TURNS Study Group
The Journal of urology, Vol.193(2), pp.587-592
02/2015
DOI: 10.1016/j.juro.2014.08.104
PMCID: PMC4307389
PMID: 25200807
Abstract
Injection of mitomycin C may increase the success of transurethral incision of the bladder neck for the treatment of bladder neck contracture. We evaluated the efficacy of mitomycin C injection across multiple institutions.
Data on all patients who underwent transurethral incision of the bladder neck with mitomycin C from 2009 to 2014 were retrospectively reviewed from 6 centers in the TURNS. Patients with at least 3 months of cystoscopic followup were included in the analysis.
A total of 66 patients underwent transurethral incision of the bladder neck with mitomycin C and 55 meeting the study inclusion criteria were analyzed. Mean ± SD patient age was 64 ± 7.6 years. Dilation or prior transurethral incision of the bladder neck failed in 80% (44 of 55) of patients. Overall 58% (32 of 55) of patients achieved resolution of bladder neck contracture after 1 transurethral incision of the bladder neck with mitomycin C at a median followup of 9.2 months (IQR 11.7). There were 23 patients who had recurrence at a median of 3.7 months (IQR 4.2), 15 who underwent repeat transurethral incision of the bladder neck with mitomycin C and 9 of 15 (60%) who were free of another recurrence at a median of 8.6 months (IQR 8.8), for an overall success rate of 75% (41 of 55). Incision with electrocautery (Collins knife) was predictive of success compared with cold knife incision (63% vs 50%, p=0.03). Four patients experienced serious adverse events related to mitomycin C and 3 needed or are planning cystectomy.
The efficacy of intralesional injection of mitomycin C at transurethral incision of the bladder neck was lower than previously reported and was associated with a 7% rate of serious adverse events.
Details
- Title: Subtitle
- Intralesional Injection of Mitomycin C at Transurethral Incision of Bladder Neck Contracture May Offer Limited Benefit: TURNS Study Group
- Creators
- Jeffrey D Redshaw - Department of Surgery, the Center for Reconstructive Urology and Men’s Health, University of Utah School of Medicine, Salt Lake City, UtahJoshua A Broghammer - Department of Urology, University of Kansas Medical Center, Kansas City, KansasThomas G Smith - Scott Department of Urology, Baylor College of Medicine, Houston, TexasBryan B Voelzke - Department of Urology, Harborview Medical Center, University of Washington School of Medicine, Seattle, WashingtonBradley A Erickson - Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IowaChristopher D McClung - Department of Urology, the Ohio State Medical Center, Columbus, OhioSean P Elliott - University of Minnesota Medical School, Minneapolis, MinnesotaNejd F Alsikafi - Department of Urology, Loyola University Chicago, Maywood, IllinoisAngela P Presson - Division of Epidemiology, University of Utah, Salt Lake City, UtahMichael E Aberger - Department of Urology, University of Kansas Medical Center, Kansas City, KansasJames R Craig - Department of Surgery, the Center for Reconstructive Urology and Men’s Health, University of Utah School of Medicine, Salt Lake City, UtahWilliam O Brant - Department of Surgery, the Center for Reconstructive Urology and Men’s Health, University of Utah School of Medicine, Salt Lake City, UtahJeremy B Myers - Department of Surgery, the Center for Reconstructive Urology and Men’s Health, University of Utah School of Medicine, Salt Lake City, Utah
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.193(2), pp.587-592
- DOI
- 10.1016/j.juro.2014.08.104
- PMID
- 25200807
- PMCID
- PMC4307389
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- Elsevier Inc
- Grant note
- National Center for Advancing Translational Sciences 8UL1TR000105; UL1RR025764 / National Institutes of Health (NIH) National Center for Research Resources
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Urology
- Record Identifier
- 9984051598402771
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