Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature

Nicole M Annest; Marta J VanBeek; Christopher J Arpey; Duane C Whitaker

doi:10.1016/j.jaad.2006.12.017

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Journal article

Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature

Nicole M Annest, Marta J VanBeek, Christopher J Arpey and Duane C Whitaker

Journal of the American Academy of Dermatology, Vol.56(6), pp.989-993

06/2007

DOI: 10.1016/j.jaad.2006.12.017

PMID: 17504715

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Abstract

Intralesional methotrexate (MTX) is an effective treatment for keratoacanthoma (KA). We sought to systematically examine response rates and adverse events in KA treated with intralesional MTX. All cases of KA treated with intralesional MTX at our institution from 1991 to 2006 were identified. A MEDLINE and PubMed search of cases of KA treated with intralesional MTX was also performed. In all, 38 cases of KA treated with intralesional MTX were identified: 18 from our institution and 20 from the literature. Intralesional MTX achieved resolution in 92%, requiring an average of 2.1 injections an average of 18 days apart. Adverse events were rare, with two reports of pancytopenia in patients with chronic renal failure. Use of single case reports, small series, and retrospective analysis are limitations. Intralesional MTX is a useful nonsurgical therapy for the treatment of KA. Histologic diagnosis before initiation of treatment is preferred. A complete blood cell count at baseline and during treatment should be considered to monitor for potential cytopenia.

Humans

Middle Aged

Male

Methotrexate - therapeutic use

Antimetabolites, Antineoplastic - administration & dosage

Retreatment

Antimetabolites, Antineoplastic - therapeutic use

Injections

Aged, 80 and over

Adult

Female

Keratoacanthoma - drug therapy

Methotrexate - administration & dosage

Aged

Retrospective Studies

Details

Title: Subtitle: Intralesional methotrexate treatment for keratoacanthoma tumors: a retrospective study and review of the literature
Creators: Nicole M Annest - Division of Mohs Surgery, Scripps Clinic and Research Institute, La Jolla, California 92037, USA. nmannest@hotmail.com
Marta J VanBeek
Christopher J Arpey
Duane C Whitaker
Resource Type: Journal article
Publication Details: Journal of the American Academy of Dermatology, Vol.56(6), pp.989-993
DOI: 10.1016/j.jaad.2006.12.017
PMID: 17504715
NLM abbreviation: J Am Acad Dermatol
ISSN: 0190-9622
eISSN: 1097-6787
Publisher: United States
Language: English
Date published: 06/2007
Academic Unit: Dermatology
Record Identifier: 9984025456702771

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