Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database

Juan Lei; Yi Wang; Zhuofei Bi; Shengneng Xue; Bing Ou; Kan Liu

doi:10.1007/s11604-019-00891-7

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Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database

Journal article

Peer reviewed

Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database

Juan Lei, Yi Wang, Zhuofei Bi, Shengneng Xue, Bing Ou and Kan Liu

Japanese journal of radiology, Vol.38(1), pp.85-92

01/2020

DOI: 10.1007/s11604-019-00891-7

PMID: 31691091

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Abstract

Intraoperative radiotherapy (IORT) has emerged as an alternative to whole-breast external beam radiotherapy (EBRT) for early breast cancer. This study aimed to investigate the risk factors for survival after IORT or whole-breast EBRT in breast cancer patients. Breast cancer patients undergoing IORT or whole-breast EBRT were included from the surveillance, epidemiology, and end results database. Risk factors for overall survival (OS) and cancer-specific survival (CSS) were identified by Cox proportional hazards regression analysis. The IORT and EBRT groups did not differ significantly in OS and CSS. T2 stage (tumor size > 2 cm) was associated with poorer OS (aHR 3.49, 95% CI 1.05-11.62, P = 0.042), whereas ER-positive tumors were associated with better OS (aHR 0.26, 95% CI 0.09-0.76, P = 0.014). IORT was not inferior than EBRT considering the OS and CSS in the short-term follow-up of early breast cancer. It may be a reasonable alternative to EBRT for early breast cancer in select patients with favorable tumor size and receptor status, given the need for long-term monitoring of local control and radiation toxicity.

Aged

Breast - radiation effects

Breast - surgery

Breast Neoplasms - radiotherapy

Breast Neoplasms - surgery

Databases, Factual

Early Detection of Cancer

Female

Humans

Intraoperative Care - methods

Middle Aged

Radiation Injuries

Retrospective Studies

Risk Factors

Survival Analysis

Details

Title: Subtitle: Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database
Creators: Juan Lei - Sun Yat-sen Memorial Hospital
Yi Wang - California State University, Dominguez Hills
Zhuofei Bi - Sun Yat-sen Memorial Hospital
Shengneng Xue - Sun Yat-sen Memorial Hospital
Bing Ou - Sun Yat-sen Memorial Hospital
Kan Liu - University of Iowa
Resource Type: Journal article
Publication Details: Japanese journal of radiology, Vol.38(1), pp.85-92
DOI: 10.1007/s11604-019-00891-7
PMID: 31691091
ISSN: 1867-1071
eISSN: 1867-108X
Language: English
Date published: 01/2020
Academic Unit: Radiology; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984318690602771

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