Journal article
Intrathecal bicuculline does not increase formalin-induced inflammation
Brain research, Vol.794(2), pp.320-324
1998
DOI: 10.1016/S0006-8993(98)00269-8
PMID: 9622664
Abstract
Intrathecal (i.t.) administration of the
γ-aminobutyric acid (GABA)
A receptor antagonist bicuculline enhances pain behaviors in the formalin test. This study examined whether bicuculline also increases the peripheral inflammation induced by formalin. Subcutaneous injection of 0.25 to 5.0% formalin in the plantar surface of one hindpaw of the rat produced a concentration-dependent increase in plasma extravasation as measured by the Evans Blue method. Pretreatment with 0.3
μg i.t. bicuculline neither enhanced nor suppressed formalin-induced plasma extravasation. This dose of bicuculline also did not affect plasma extravasation induced by injection of 3% kaolin/3% carrageenan in the knee of the rat. These data indicate that the enhancement of formalin-induced pain behaviors by i.t. bicuculline is not secondary to enhanced peripheral inflammation, but more likely reflects enhancement of nociceptive transmission in the spinal cord.
Details
- Title: Subtitle
- Intrathecal bicuculline does not increase formalin-induced inflammation
- Creators
- Jerry M JohnMegumi KanekoDonna L Hammond
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.794(2), pp.320-324
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(98)00269-8
- PMID
- 9622664
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1998
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006303202771
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