Journal article
Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial
The journal of spinal cord medicine, Vol.39(6), pp.655-664
11/01/2016
DOI: 10.1179/2045772315Y.0000000048
PMCID: PMC5137573
PMID: 26208177
Abstract
Context: Spinal cord injury (SCI) can cause irreversible damage to neural tissues. However, there is currently no effective treatment for SCI. The therapeutic potential of adipose-derived mesenchymal stem cells (ADMSCs) has been emerged.
Objective: We evaluated the effects and safety of the intrathecal transplantation of autologous ADMSCs in patients with SCI.
Participants/Interventions: Fourteen patients with SCI were enrolled (12 for ASIA A, 1 for B, and 1 for D; duration of impairments 3-28 months). Six patients were injured at cervical, 1 at cervico-thoracic, 6 at thoracic, and 1 at lumbar level. Autologous ADMSCs were isolated from lipoaspirates of patients' subcutaneous fat tissue and 9 × 10
7
ADMSCs per patient were administered intrathecally through lumbar tapping. MRI, hematological parameters, electrophysiology studies, and ASIA motor/sensory scores were assessed before and after transplantation.
Results: ASIA motor scores were improved in 5 patients at 8 months follow-up (1-2 grades at some myotomes). Voluntary anal contraction improvement was seen in 2 patients. ASIA sensory score recovery was seen in 10, although degeneration was seen in 1. In somatosensory evoked potential test, one patient showed median nerve improvement. There was no interval change of MRI between baseline and 8 months post-transplantation. Four adverse events were observed in three patients: urinary tract infection, headache, nausea, and vomiting.
Conclusions: Over the 8 months of follow-up, intrathecal transplantation of autologous ADMSCs for SCI was free of serious adverse events, and several patients showed mild improvements in neurological function. Patient selection, dosage, and delivery method of ADMSCs should be investigated further.
Details
- Title: Subtitle
- Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial
- Creators
- Junseok W. Hur - Korea UniversityTai-Hyoung Cho - Korea UniversityDong-Hyuk Park - Korea UniversityJang-Bo Lee - Korea UniversityJung-Yul Park - Department of Neurosurgery, Korea University College of Medicine, Korea University Anam HospitalYong-Gu Chung - Korea University
- Resource Type
- Journal article
- Publication Details
- The journal of spinal cord medicine, Vol.39(6), pp.655-664
- Publisher
- Taylor & Francis
- DOI
- 10.1179/2045772315Y.0000000048
- PMID
- 26208177
- PMCID
- PMC5137573
- ISSN
- 1079-0268
- eISSN
- 2045-7723
- Language
- English
- Date published
- 11/01/2016
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984460322602771
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