Journal article
Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data
Journal of pharmacy practice, Vol.36(1), pp.173-175
02/2023
DOI: 10.1177/08971900211021286
PMID: 34080465
Abstract
The toxicokinetics of pediatric intravenous (IV) acetaminophen (APAP) in overdose is not well described and few case reports with serial APAP concentrations allowing for calculations of half-life exist. Here, we report toxicokinetic data from a case of an unintentional IV APAP overdose in a 12-month-old male who was treated with NAC.
Case Report:
A 12-month-old (former 24 week gestational age), 8.7 kg male was hospitalized after an uneventful colostomy reversal. In the postoperative unit, the patient unintentionally received 1000 mg IV (114.9 mg/kg) acetaminophen instead of the intended 100 mg IV. Serial acetaminophen concentrations were drawn. The patient received IV Nacetylcysteine and ultimately had no adverse outcomes.
Discussion:
This case report adds to the existing literature regarding toxicokinetics of IV APAP in infants. Our patient had a calculated ke of 0.263 h-1, correlating with a half-life of 2.63 hours. Based on current available data, the half-life of IV APAP in infants varies (2.6 to 4.9 hours). The reason for this variation is unknown and further research is needed in this area.
Details
- Title: Subtitle
- Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data
- Creators
- Joshua Trebach - New York UniversitySarah G. Mahonski - New York City Department of Health and Mental HygieneKristina Melchert - Maria Fareri Children's HospitalMary Ann Howland - St. John's UniversityWilliam K. Chiang - New York City Department of Health and Mental Hygiene
- Resource Type
- Journal article
- Publication Details
- Journal of pharmacy practice, Vol.36(1), pp.173-175
- Publisher
- Sage
- DOI
- 10.1177/08971900211021286
- PMID
- 34080465
- ISSN
- 0897-1900
- eISSN
- 1531-1937
- Number of pages
- 3
- Language
- English
- Electronic publication date
- 06/03/2021
- Date published
- 02/2023
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984296985502771
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