Journal article
Intravenous iron therapy for patients with iron deficiency and heart failure: a systematic review and meta-analysis of randomized controlled trials
Proceedings - Baylor University. Medical Center, Vol.37(3), pp.466-476
2024
DOI: 10.1080/08998280.2024.2326387
PMCID: PMC11018061
PMID: 38628339
Abstract
ntroduction
Heart failure (HF) presents a significant health challenge, with intravenous (IV) iron therapy considered a potential treatment avenue.
Method
We assessed IV iron therapy’s efficacy in HF patients with concurrent iron deficiency versus standard of care. Primary outcomes included the composite of HF hospitalizations or cardiovascular-related mortality, HF hospitalizations, and all-cause, HF, and cardiovascular mortality rates. Secondary measures encompassed improvements in New York Heart Association functional classification, quality of life, 6-minute walk test, left ventricular ejection fraction, and adverse events. We used a random-effects model to compute relative risk (RR) or mean difference (MD) with 95% confidence intervals (CIs).
Results
Based on an analysis of 14 randomized controlled trials involving 6614 patients, IV iron therapy significantly reduced composite outcome (RR: 0.84, 95% CI: 0.73, 0.96; P = 0.01) and HF hospitalizations (RR: 0.74, 95% CI: 0.61, 0.89; P = 0.002) compared to standard of care. Mortality rates showed no significant difference. IV iron therapy improved New York Heart Association functional classification, quality of life, and 6-minute walk test, with no major impact on left ventricular ejection fraction. Adverse events remained stable.
Conclusions
IV iron therapy holds promise for diminishing HF hospitalizations and enhancing quality of life and 6-minute walk test in HF patients. Yet, its effect on all-cause or cardiovascular mortalities appears limited.
Details
- Title: Subtitle
- Intravenous iron therapy for patients with iron deficiency and heart failure: a systematic review and meta-analysis of randomized controlled trials
- Creators
- Mohammed Mhanna - University of IowaMichael C. Sauer - University of IowaAhmad Al-Abdouh - University of KentuckyAhmad Jabri - Case Western Reserve UniversityAzizullah Beran - Indiana University – Purdue University IndianapolisMahmoud Barbarawi - University of ConnecticutShareef Mansour - University of IowaElias B. Hanna - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Proceedings - Baylor University. Medical Center, Vol.37(3), pp.466-476
- Publisher
- Taylor & Francis
- DOI
- 10.1080/08998280.2024.2326387
- PMID
- 38628339
- PMCID
- PMC11018061
- ISSN
- 0899-8280
- eISSN
- 1525-3252
- Alternative title
- Intravenous Iron Therapy For Patients With Iron Deficiency and Heart Failure
- Language
- English
- Date published
- 2024
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984586460002771
Metrics
3 Record Views