Journal article
Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
Cell reports (Cambridge), Vol.29(8), pp.2398-2407.e4
11/19/2019
DOI: 10.1016/j.celrep.2019.10.067
PMCID: PMC6914265
PMID: 31747608
Abstract
A reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a large normative sample (n = 1,482). Surprisingly, hemispherectomy subjects and controls all showed strong and equivalent intrahemispheric connectivity between brain regions typically assigned to the same functional network. Connectivity between parts of different networks, however, was markedly increased for almost all hemispherectomy participants and across all networks. These results support the hypothesis of a shared set of functional networks that underlie cognition and suggest that between-network interactions may characterize functional reorganization in hemispherectomy.
Details
- Title: Subtitle
- Intrinsic Functional Connectivity of the Brain in Adults with a Single Cerebral Hemisphere
- Creators
- Dorit Kliemann - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: dorit@caltech.eduRalph Adolphs - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USAJ Michael Tyszka - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USABruce Fischl - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA 02114, USA; Division of Health Sciences and Technology and Engineering and Computer Science MIT, Cambridge, MA 02139, USAB T Thomas Yeo - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Electrical and Computer Engineering, Centre for Sleep and Cognition, Clinical Imaging Research Centre, N.1 Institute for Health and Memory Networks Program, National University of Singapore, Singapore 119077, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, SingaporeRemya Nair - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USAJulien Dubois - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USALynn K Paul - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.29(8), pp.2398-2407.e4
- Publisher
- United States
- DOI
- 10.1016/j.celrep.2019.10.067
- PMID
- 31747608
- PMCID
- PMC6914265
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- U01 NS086625 / NINDS NIH HHS R01 AG016495 / NIA NIH HHS R01 EB019956 / NIBIB NIH HHS R01 EB023281 / NIBIB NIH HHS R01 NS083534 / NINDS NIH HHS P41 EB015896 / NIBIB NIH HHS R01 AG008122 / NIA NIH HHS U01 MH117023 / NIMH NIH HHS S10 RR019307 / NCRR NIH HHS R01 NS105820 / NINDS NIH HHS R56 AG064027 / NIA NIH HHS R21 EB018907 / NIBIB NIH HHS R01 NS052585 / NINDS NIH HHS R21 NS072652 / NINDS NIH HHS R01 EB006758 / NIBIB NIH HHS S10 RR023043 / NCRR NIH HHS R01 NS070963 / NINDS NIH HHS S10 RR023401 / NCRR NIH HHS P50 MH094258 / NIMH NIH HHS
- Language
- English
- Date published
- 11/19/2019
- Academic Unit
- Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065366702771
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