Journal article
Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging
Journal of biomedical nanotechnology, Vol.14(5), pp.900-909
05/01/2018
DOI: 10.1166/jbn.2018.2498
PMCID: PMC6007016
PMID: 29883560
Abstract
Manganese-based nanoparticles (NPs) have recently attracted much attention in the field of biomedical imaging due to their impressive enhanced T-1 contrast ability. Although the reported manganese-based NPs have exhibited good imaging capabilities as contrast agents, it is still urgent to develop novel multifunctional manganese-based imaging probes for future biomedical imaging, especially PET/MRI probes. Herein, we present chelator-free zirconium-89 (Zr-89, t(1/2): 78.4 h) labeling of manganese oxide NPs (Mn3O4@PEG) with similar to 78% labeling yield and good stability. Serial positron emission tomography (PET) and magnetic resonance imaging (MRI) studies non-invasively assessed the biodistribution patterns of the NPs and the feasibility of in vivo dual-modality imaging and lymph-node mapping. Since Mn3O4 NPs exhibited desirable properties for enhanced T-1 imaging and the simplicity of chelator-free radiolabeling, [Zr-89]Mn3O4@PEG NPs offer a novel, simple, safe and accurate nanoplatforms for future precise cancer imaging and diagnosis.
Details
- Title: Subtitle
- Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging
- Creators
- Yonghua Zhan - Xidian UniversityEmily B. Ehlerding - University of Wisconsin–MadisonSixiang Shi - University of Wisconsin–MadisonStephen A. Graves - University of Wisconsin–MadisonShreya Goel - Univ Wisconsin, Dept Radiol, Madison, WI 53705 USAJonathan W. Engle - University of Wisconsin–MadisonJimin Liang - Xidian UniversityWeibo Cai - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical nanotechnology, Vol.14(5), pp.900-909
- DOI
- 10.1166/jbn.2018.2498
- PMID
- 29883560
- PMCID
- PMC6007016
- NLM abbreviation
- J Biomed Nanotechnol
- ISSN
- 1550-7033
- eISSN
- 1550-7041
- Publisher
- Amer Scientific Publishers
- Number of pages
- 10
- Grant note
- R01EB021336 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) 81227901; 81571725; 81530058; 81230033; 31371006; 61405149; 81660505; 81627807 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) University of Wisconsin-Madison JB171204 / Fundamental Research Funds for the Central Universities NIBIB/NCI 1R01CA169365; 1R01CA205101; 1R01EB021336; T32GM008505; T32CA009206; P30CA014520 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 125246-RSG-13-099-01-CCE / American Cancer Society T32GM008505 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 2017JM8057 / Natural Science Basic Research Plan in Shaanxi Province of China
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984383905002771
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