Invasive breast cancer among Alaska Native women in Alaska

Sarah H Nash; Garrett Zimpelman; Barbara Stillwater; Matthew Olnes; Ellen Provost

doi:10.1080/22423982.2019.1633190

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Invasive breast cancer among Alaska Native women in Alaska

Journal article

Open access

Peer reviewed

Invasive breast cancer among Alaska Native women in Alaska

Sarah H Nash, Garrett Zimpelman, Barbara Stillwater, Matthew Olnes and Ellen Provost

International journal of circumpolar health, Vol.78(1), pp.1633190-1633190

01/01/2019

DOI: 10.1080/22423982.2019.1633190

PMCID: PMC6598524

PMID: 31234738

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Abstract

Female breast cancer is the most common cancer diagnosed among Alaska Native (AN) women. We examined characteristics of and trends for female breast cancer among AN women. We assessed descriptive statistics, incidence trends (1969–2014), and cause-specific survival for female breast cancers recorded in the Alaska Native Tumor Registry. Results indicated that the majority of breast cancers among AN were diagnosed among women aged over 50 years, at local stage, and with Hormone receptor (HR) + /Human Epidermal Growth Factor (HER) 2 − subtype. Five-year average incidence (95% CI) in the most recent time-period (2009–2014) was 145.0/100,000 (130.4, 159.5)); this was not statistically different from the previous time-period. Survival from breast cancer was high and varied by stage and cancer subtype. Hazard of death was greater among those diagnosed with regional/distant/unknown disease, relative to local disease (HR (95%CI): 4.65 (1.66, 12.98)), and higher among those with HER2 − /HR − cancers, relative to those with HER2-/HR+ cancers (HR (95%CI): 6.59 (2.23, 19.49)). This study provides a comprehensive description of breast cancer among AN women, providing new and updated information on clinical and demographic factors, cancer incidence trends, regional variations and breast cancer survival. Abbreviations: AIAN: American Indian/Alaska Native; AN: Alaska Native; ANMC: Alaska Native Medical Center; ANTR: Alaska Native Tumor Registry; CI: Confidence Interval; HR: Hazard Ratio; ICD-O-3: International Classification of Diseases for Oncology – Third Edition; NHW – Non-Hispanic Whites; SEER: Surveillance, Epidemiology and End Results.

breast cancer

cancer surveillance

Native American

SEER

tumor registry

Details

Title: Subtitle: Invasive breast cancer among Alaska Native women in Alaska
Creators: Sarah H Nash - Alaska Native Epidemiology Center, Community Health Services, Alaska Native Tribal Health Consortium
Garrett Zimpelman - Alaska Native Epidemiology Center, Community Health Services, Alaska Native Tribal Health Consortium
Barbara Stillwater - Clinical and Research Services, Community Health Services, Alaska Native Tribal Health Consortium
Matthew Olnes - Alaska Native Medical Center, Alaska Native Tribal Health Consortium
Ellen Provost - Alaska Native Epidemiology Center, Community Health Services, Alaska Native Tribal Health Consortium
Resource Type: Journal article
Publication Details: International journal of circumpolar health, Vol.78(1), pp.1633190-1633190
Publisher: Taylor & Francis
DOI: 10.1080/22423982.2019.1633190
PMID: 31234738
PMCID: PMC6598524
ISSN: 1239-9736
eISSN: 2242-3982
Grant note: contract number HHSN26120130010I; Task Order HHSN26100005 / ; ; U1B1IHS008-13-01 / ; ;
Alternative title: S. H. NASH ET AL
Language: English
Date published: 01/01/2019
Academic Unit: Epidemiology; Center for Social Science Innovation
Record Identifier: 9984214838702771

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