Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Benjamin J Park; Loreen Herwaldt; Peter G Pappas; Kathleen A Wannemuehler; Barbara D Alexander; Elias J Anaissie; David R Andes; John W Baddley; Janice M Brown; Lisa M Brumble; Alison G Freifeld; Susan Hadley; James I Ito; Carol A Kauffman; G Marshall Lyon; Kieren A Marr; Vicki A Morrison; Genovefa Papanicolaou; Thomas F Patterson; Trish M Perl; Mindy G Schuster; Randall Walker; John R Wingard; Thomas J Walsh; Dimitrios P Kontoyiannis

doi:10.3201/eid1710.110087

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Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Journal article

Open access

Peer reviewed

Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Benjamin J Park, Loreen Herwaldt, Peter G Pappas, Kathleen A Wannemuehler, Barbara D Alexander, Elias J Anaissie, David R Andes, John W Baddley, Janice M Brown, Lisa M Brumble, …

Emerging infectious diseases, Vol.17(10), pp.1855-1864

10/2011

DOI: 10.3201/eid1710.110087

PMCID: PMC3311117

PMID: 22000355

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Abstract

Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

Mycoses - epidemiology

United States - epidemiology

Follow-Up Studies

Opportunistic Infections - epidemiology

Humans

Middle Aged

Mycoses - microbiology

Male

Antifungal Agents - therapeutic use

Incidence

Opportunistic Infections - microbiology

Transplantation - adverse effects

Opportunistic Infections - drug therapy

Mycoses - drug therapy

Adult

Female

Cohort Studies

Details

Title: Subtitle: Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006
Creators: Benjamin J Park - Centers for Disease Control and Prevention, Atlanta, Georgia, USA. bpark1@cdc.gov
Loreen Herwaldt
Peter G Pappas
Kathleen A Wannemuehler
Barbara D Alexander
Elias J Anaissie
David R Andes
John W Baddley
Janice M Brown
Lisa M Brumble
Alison G Freifeld
Susan Hadley
James I Ito
Carol A Kauffman
G Marshall Lyon
Kieren A Marr
Vicki A Morrison
Genovefa Papanicolaou
Thomas F Patterson
Trish M Perl
Mindy G Schuster
Randall Walker
John R Wingard
Thomas J Walsh
Dimitrios P Kontoyiannis
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.17(10), pp.1855-1864
DOI: 10.3201/eid1710.110087
PMID: 22000355
PMCID: PMC3311117
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Grant note: U01 CI000286 / NCPDCID CDC HHS 5U01CI000286-05 / NCPDCID CDC HHS
Language: English
Date published: 10/2011
Academic Unit: Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9984094653502771

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