Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis

Greg T Siwek; Kirsty J Dodgson; Margarida de Magalhaes-Silverman; Luther A Bartelt; Sara B Kilborn; Peter L Hoth; Daniel J Diekema; Michael A Pfaller

doi:10.1086/422723

Back

Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis

Journal article

Open access

Peer reviewed

Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis

Greg T Siwek, Kirsty J Dodgson, Margarida de Magalhaes-Silverman, Luther A Bartelt, Sara B Kilborn, Peter L Hoth, Daniel J Diekema and Michael A Pfaller

Clinical infectious diseases, Vol.39(4), pp.584-587

08/15/2004

DOI: 10.1086/422723

PMID: 15356827

Files and links (1)

url

https://doi.org/10.1086/422723View

Published (Version of record) Open Access

Abstract

We report 4 cases of invasive zygomycosis in hematopoietic stem cell transplant recipients, all occurring after May 2003, when voriconazole began to be used as antifungal prophylaxis. No cases of zygomycosis had been detected in this population in the 3 years prior to May 2003. All 4 patients were receiving immunosuppressive therapy for presumed graft-versus-host disease. Profoundly immunosuppressed patients receiving voriconazole prophylaxis remain at risk for less-common pathogens that are intrinsically resistant to this agent.

Fungi - drug effects

Humans

Immunosuppressive Agents - therapeutic use

Middle Aged

Zygomycosis - prevention & control

Fungi - isolation & purification

Male

Rhizopus - drug effects

Antifungal Agents - therapeutic use

Zygomycosis - epidemiology

Pyrimidines - therapeutic use

Hematopoietic Stem Cell Transplantation - adverse effects

Voriconazole

Adult

Female

Graft vs Host Disease - prevention & control

Rhizopus - isolation & purification

Triazoles - therapeutic use

Details

Title: Subtitle: Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis
Creators: Greg T Siwek - Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Kirsty J Dodgson
Margarida de Magalhaes-Silverman
Luther A Bartelt
Sara B Kilborn
Peter L Hoth
Daniel J Diekema
Michael A Pfaller
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.39(4), pp.584-587
Publisher: United States
DOI: 10.1086/422723
PMID: 15356827
ISSN: 1058-4838
eISSN: 1537-6591
Language: English
Date published: 08/15/2004
Academic Unit: Infectious Diseases; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Pathology; Family and Community Medicine; Internal Medicine
Record Identifier: 9983986268402771

Metrics

14 Record Views

236 Times Cited - Web of Science

See more details