Journal article
Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States
Frontiers in endocrinology (Lausanne), Vol.10, pp.414-414
2019
DOI: 10.3389/fendo.2019.00414
PMCID: PMC6610317
PMID: 31316466
Abstract
Introduction:
Several studies have suggested that vitamin B12 deficiency is more common in obese individuals. We evaluated the cross-sectional associations of serum vitamin B12 concentrations with obesity in a nationally representative sample of adults in the United States.
Methods:
We included 9,075 participants aged ≥20 years in the National Health and Nutrition Examination Survey 2011–2014. Serum vitamin B12 concentrations were measured by electrochemiluminescence immunoassay. Obesity was defined as BMI ≥30 kg/m
2
. We used logistic regression with sample weights to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
Serum vitamin B12 concentrations were lower among obese adults compared with non-obese adults. After adjustment for age, gender, race/ethnicity, socioeconomic status, dietary and lifestyle factors, use of medications that could affect the serum vitamin B12 levels, dietary supplement use and fasting time, the multivariable-adjusted ORs (95% CIs) of obesity were 1.00 (reference), 0.95 (0.79, 1.14), 0.86 (0.74, 0.99), and 0.71 (0.60, 0.84) (
p
for trend <0.001) for increasing quartiles of serum vitamin B12 concentrations.
Conclusions:
In a large nationally representative sample of U.S. adults, higher serum vitamin B12 levels were inversely associated with obesity. Further investigation is needed to understand the underlying mechanisms.
Details
- Title: Subtitle
- Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States
- Creators
- Yangbo Sun - , , , , , , , ,Minxian Sun - , , , , , , , ,Buyun Liu - , , , , , , , ,Yang Du - , , , , , , , ,Shuang Rong - , , , , , , , ,Guifeng Xu - , , , , , , , ,Linda G Snetselaar - , , , , , , , ,Wei Bao - , , , , , , , ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in endocrinology (Lausanne), Vol.10, pp.414-414
- DOI
- 10.3389/fendo.2019.00414
- PMID
- 31316466
- PMCID
- PMC6610317
- NLM abbreviation
- Front Endocrinol (Lausanne)
- ISSN
- 1664-2392
- eISSN
- 1664-2392
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2019
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215047202771
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