Journal article
Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study
Nutrients, Vol.9(3), p.294
03/17/2017
DOI: 10.3390/nu9030294
PMCID: PMC5372957
PMID: 28304331
Abstract
Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study aimed to examine the associations of plasma chromium levels with T2DM and pre-diabetes mellitus (pre-DM). We conducted a case-control study involving 1471 patients with newly diagnosed T2DM, 682 individuals with newly diagnosed pre-DM, and 2290 individuals with normal glucose tolerance in a Chinese population from 2009 to 2014. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Plasma chromium levels were lower in the T2DM and pre-DM groups than in the control group (median: 3.68 μg/L, 3.61 μg/L, 3.97 μg/L, respectively,
< 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for T2DM across increasing quartiles of plasma chromium levels were 1 (referent), 0.67 (0.55-0.83), 0.64 (0.51-0.79), and 0.58 (0.46-0.73), respectively (
for trend <0.001). The corresponding odds ratios (95% confidence interval) for pre-DM were 1 (referent), 0.70 (0.54-0.91), 0.67 (0.52-0.88), and 0.58 (0.43-0.78), respectively (
for trend < 0.001). Our results indicated that plasma chromium concentrations were inversely associated with T2DM and pre-DM in Chinese adults.
Details
- Title: Subtitle
- Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study
- Creators
- Sijing Chen - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. sijingchen19@sina.comXiaoling Jin - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiaolingking@126.comZhilei Shan - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. shanzhilei3118@126.comShuzhen Li - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. M201575207@hust.edu.cnJiawei Yin - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. M201575208@hust.edu.cnTaoping Sun - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. suntaoping@163.comCheng Luo - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. milkluobo@sina.comWei Yang - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yw8278@hotmail.comPing Yao - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yaoping@mails.tjmu.edu.cnKaifeng Yu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. bwinds@yeah.netYan Zhang - Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China. zhangyan@angelyeast.comQian Cheng - Hubei Provincial Key Laboratory of Yeast Function, Yichang 443003, China. chengqian@angelyeast.comJinquan Cheng - Shenzhen Center for Disease Control and Prevention, Shenzhen 51805, China. cjinquan@szcdc.netWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. wei-bao@uiowa.eduLiegang Liu - Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. lgliu@mails.tjmu.edu.cn
- Resource Type
- Journal article
- Publication Details
- Nutrients, Vol.9(3), p.294
- DOI
- 10.3390/nu9030294
- PMID
- 28304331
- PMCID
- PMC5372957
- NLM abbreviation
- Nutrients
- ISSN
- 2072-6643
- eISSN
- 2072-6643
- Publisher
- Switzerland
- Grant note
- P30 ES005605 / NIEHS NIH HHS
- Language
- English
- Date published
- 03/17/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983996055502771
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