Journal article
Inverse association of plasma vanadium levels with newly diagnosed type 2 diabetes in a Chinese population
American journal of epidemiology, Vol.180(4), pp.378-384
08/15/2014
DOI: 10.1093/aje/kwu148
PMID: 25005791
Abstract
Vanadium compounds have been proposed to have beneficial effects on the pathogenesis and complications of type 2 diabetes. Our objective was to evaluate the association between plasma vanadium levels and type 2 diabetes. We performed a case-control study involving 1,598 Chinese subjects with or without newly diagnosed type 2 diabetes (December 2004-December 2007). Cases and controls were frequency-matched by age and sex. Plasma vanadium concentrations were measured and compared between groups. Analyses showed that plasma vanadium concentrations were significantly lower in cases with newly diagnosed type 2 diabetes than in controls (P = 0.001). Mean plasma vanadium levels in participants with and without diabetes were 1.0 μg/L and 1.2 μg/L, respectively. Participants in the highest quartile of plasma vanadium concentration had a notably lower risk of newly diagnosed type 2 diabetes (odds ratio = 0.26, 95% confidence interval: 0.19, 0.35; P < 0.001), compared with persons in the lowest quartile. The trend remained significant after adjustment for known risk factors and in further stratification analyses. Our results suggested that plasma vanadium concentrations were inversely associated with newly diagnosed type 2 diabetes in this Chinese population.
Details
- Title: Subtitle
- Inverse association of plasma vanadium levels with newly diagnosed type 2 diabetes in a Chinese population
- Creators
- Xia WangTaoping SunJun LiuZhilei ShanYilin JinSijing ChenWei BaoFrank B HuLiegang Liu
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.180(4), pp.378-384
- Publisher
- United States
- DOI
- 10.1093/aje/kwu148
- PMID
- 25005791
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Language
- English
- Date published
- 08/15/2014
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995009002771
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