Journal article
Investigating White Matter Tract Microstructural Changes at Six-Twelve Weeks following Mild Traumatic Brain Injury: A Combined Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging Study
Journal of neurotrauma, Vol.38(16), pp.2255-2263
08/15/2021
DOI: 10.1089/neu.2020.7310
PMID: 33307950
Abstract
Using diffusion-weighted imaging (DWI), research has demonstrated changes suggestive of damage to white matter tracts (WMT) following mild traumatic brain injury (mTBI). Yet due to the predominant use of the diffusion tensor imaging (DTI) model, which has numerous well-established limitations, it has not yet been possible to clearly examine the nature of changes to WMT microstructure following mTBI. This study used a second DWI-based technique, neurite orientation dispersion and density imaging (NODDI), in combination with DTI to measure microstructural changes within the corpus callosum, three long association and one projection WMTs at 6-12 weeks following mTBI, compared with matched trauma controls (TC). Between-groups differences were identified across all WMT for the DTI metric fractional anisotropy (FA), and the NODDI metrics orientation dispersion index (ODI) and isotropic volume fraction (ISO). No statistically significant between-groups differences were found for other DTI and NODDI metrics. Our study revealed that reduced FA was accompanied by increased ODI, suggesting that mTBI results in reduced coherence of axonal fiber bundles within the studied WMTs. These between-groups differences in WMT microstructure were found at 6-12 weeks post-injury, which suggests that structural recovery is not yet complete towards end of the typical 3-month recovery period.
Details
- Title: Subtitle
- Investigating White Matter Tract Microstructural Changes at Six-Twelve Weeks following Mild Traumatic Brain Injury: A Combined Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging Study
- Creators
- Lucy E. Oehr - The University of MelbourneJoseph Yuan-Mou Yang - The University of MelbourneJian Chen - Murdoch Children's Research InstituteJerome J. Maller - Monash Alfred Psychiatry Research centreMarc L. Seal - Murdoch Children's Research InstituteJacqueline F. I. Anderson - The University of Melbourne
- Resource Type
- Journal article
- Publication Details
- Journal of neurotrauma, Vol.38(16), pp.2255-2263
- DOI
- 10.1089/neu.2020.7310
- PMID
- 33307950
- NLM abbreviation
- J Neurotrauma
- ISSN
- 0897-7151
- eISSN
- 1557-9042
- Publisher
- Mary Ann Liebert, Inc
- Number of pages
- 9
- Grant note
- Murdoch Childrens Research Institute University of Melbourne Victorian Government's Operational Infrastructure Support Program Royal Children's Hospital Foundation Royal Children's Hospital University of Melbourne Department of Paediatrics
- Language
- English
- Date published
- 08/15/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984848426102771
Metrics
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