Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study

Vincent A Magnotta; Michael L Adix; Arvind Caprahan; Kelvin Lim; Randy Gollub; Nancy C Andreasen

doi:10.1016/j.pscychresns.2007.10.005

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Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study

Journal article

Peer reviewed

Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study

Vincent A Magnotta, Michael L Adix, Arvind Caprahan, Kelvin Lim, Randy Gollub and Nancy C Andreasen

Psychiatry research, Vol.163(3), pp.193-200

08/30/2008

DOI: 10.1016/j.pscychresns.2007.10.005

PMCID: PMC3847814

PMID: 18656332

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https://www.ncbi.nlm.nih.gov/pmc/articles/3847814View

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Abstract

Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.

Diagnostic and Statistical Manual of Mental Disorders

Pilot Projects

Thalamus - physiopathology

Anisotropy

Schizophrenia - physiopathology

Humans

Diffusion Magnetic Resonance Imaging

Adult

Female

Male

Cerebellum - physiopathology

Nerve Net - physiopathology

Details

Title: Subtitle: Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study
Creators: Vincent A Magnotta - Department of Radiology, The University of Iowa, Iowa, Iowa City, IA 52242, USA. vincent-magnotta@uiowa.edu
Michael L Adix
Arvind Caprahan
Kelvin Lim
Randy Gollub
Nancy C Andreasen
Resource Type: Journal article
Publication Details: Psychiatry research, Vol.163(3), pp.193-200
DOI: 10.1016/j.pscychresns.2007.10.005
PMID: 18656332
PMCID: PMC3847814
NLM abbreviation: Psychiatry Res
ISSN: 0165-1781
eISSN: 1872-7123
Publisher: Ireland
Grant note: R01 MH040856 / NIMH NIH HHS R01 MH060990 / NIMH NIH HHS
Language: English
Date published: 08/30/2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003454902771

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