Investigating the relationship between stroke and obstructive sleep apnea

M E Dyken; V K Somers; T Yamada; Zong-Ying Ren; M B Zimmerman

doi:10.1161/01.STR.27.3.401

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Investigating the relationship between stroke and obstructive sleep apnea

Journal article

Peer reviewed

Investigating the relationship between stroke and obstructive sleep apnea

M E Dyken, V K Somers, T Yamada, Zong-Ying Ren and M B Zimmerman

Stroke (1970), Vol.27(3), pp.401-407

03/1996

DOI: 10.1161/01.STR.27.3.401

PMID: 8610303

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Abstract

We aimed to prospectively determine whether the incidence of obstructive sleep apnea in patients with recent stroke was significantly different from that of a sex- and age-matched control group with no major medical problems. We prospectively performed overnight polysomnography in 24 patients with a recent stroke (13 men and 11 women; mean age [+/- SD], 64.6 +/- 10.4 years) and 27 subjects without stroke (13 men and 14 women; mean age, 61.6 +/- 8.8 years). Patients with either ischemic or hemorrhagic stroke were entered into this study. Polysomnographic evaluations were performed within approximately 2 to 5 weeks after each patient's stroke. Obstructive sleep apnea was found in 10 of 13 men with stroke (77%) and in only 3 of 13 male subjects without stroke (23%) (P=.0169). Seven of 11 women with stroke (64%) had obstructive sleep apnea, while only 2 of 14 female subjects without stroke (14%) had obstructive sleep apnea (P=.0168). For men with stroke, the mean apnea/hypopnea index (+/- SE) was 21.5 +/- 4.2 events per hour, while for male subjects without stroke it was 4.8 +/- 1.8 events per hour (P=.0014). For women with stroke the mean apnea/hypopnea index was 31.6 +/- 8.8 events per hour, while for female subjects without stroke it was 2.9 +/- 1.6 events per hour (P=.0024). The 4-year mortality for patients with stroke was 20.8%. All patients with stroke who died had obstructive sleep apnea. Patients with stroke have an increased incidence of obstructive sleep apnea compared with normal sex- and age-matched control subjects. Hypoxia and hemodynamic responses to obstructive sleep apnea may have predisposed these patients to stroke.

Hemodynamics

Brain Ischemia - complications

Sleep Apnea Syndromes - physiopathology

Prospective Studies

Follow-Up Studies

Humans

Middle Aged

Risk Factors

Male

Survival Rate

Polysomnography

Sleep Apnea Syndromes - complications

Case-Control Studies

Cause of Death

Incidence

Sleep Stages

Cerebrovascular Disorders - complications

Snoring - complications

Aged, 80 and over

Female

Hypoxia - physiopathology

Aged

Cerebral Hemorrhage - complications

Details

Title: Subtitle: Investigating the relationship between stroke and obstructive sleep apnea
Creators: M E Dyken - Department of Neurology, Sleep Disorders Center, University of Iowa College of Medicine, Iowa City, 52242, USA
V K Somers
T Yamada
Zong-Ying Ren
M B Zimmerman
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.27(3), pp.401-407
DOI: 10.1161/01.STR.27.3.401
PMID: 8610303
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: United States
Language: English
Date published: 03/1996
Academic Unit: Neurology; Biostatistics
Record Identifier: 9983997328202771

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