Investigating the role of the corpus callosum in regulating motor overflow in multiple sclerosis

Anne-Marie Ternes; Jerome J. Maller; Joanne Fielding; Patricia Addamo; Owen White; Nellie Georgiou-Karistianis

doi:10.1007/s00415-013-6914-2

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Investigating the role of the corpus callosum in regulating motor overflow in multiple sclerosis

Journal article

Peer reviewed

Investigating the role of the corpus callosum in regulating motor overflow in multiple sclerosis

Anne-Marie Ternes, Jerome J. Maller, Joanne Fielding, Patricia Addamo, Owen White and Nellie Georgiou-Karistianis

Journal of neurology, Vol.260(8), pp.1997-2004

08/01/2013

DOI: 10.1007/s00415-013-6914-2

PMID: 23589195

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Abstract

The corpus callosum (CC) is commonly affected in multiple sclerosis (MS), however, sensitive behavioral measures of MS-related CC pathology are lacking. The CC is considered a key structure in the mediation of a type of involuntary movement known as motor overflow. In this study, we sought to characterize the impact of CC damage on motor overflow in MS. Twenty MS participants and 20 controls performed a unilateral force production task. Motor overflow (involuntary force) in the non-active hand was measured while the active hand performed the task. CC volume and lesion load were calculated for MS participants using T2-weighted MRI. We found no group differences in motor overflow; however, motor overflow correlated significantly with MS disease severity [Expanded disability status scale (EDSS)]. CC damage (lesions and decreased volume) did not correlate with motor overflow. This study suggests that CC damage may not directly lead to changes in the regulation of motor overflow. Rather, findings support the notion that a wider network of structures may mediate the production and suppression of motor overflow.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Investigating the role of the corpus callosum in regulating motor overflow in multiple sclerosis
Creators: Anne-Marie Ternes - Monash University
Jerome J. Maller - Monash Alfred Psychiatry Research centre
Joanne Fielding - Monash University
Patricia Addamo - Victoria University
Owen White - The Royal Melbourne Hospital
Nellie Georgiou-Karistianis - Monash University
Resource Type: Journal article
Publication Details: Journal of neurology, Vol.260(8), pp.1997-2004
DOI: 10.1007/s00415-013-6914-2
PMID: 23589195
NLM abbreviation: J Neurol
ISSN: 0340-5354
eISSN: 1432-1459
Publisher: Springer Nature
Number of pages: 8
Grant note: School of Psychology and Psychiatry, Monash University; Monash University
Language: English
Date published: 08/01/2013
Academic Unit: Radiology
Record Identifier: 9984848426002771

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