Journal article
Investigation of azobenzene-functionalized (2-phenylpyridine)Pt(II) complexes as switchable luminescent probes for amyloid fibrils
Polyhedron, Vol.269, 117394
03/01/2025
DOI: 10.1016/j.poly.2025.117394
Abstract
Absorption and emission properties of two cyclometalated 2-phenylpyridine platinum(II) complexes functionalized with photoswitchable azobenzene groups were examined. The complexes were non-luminescent in solution, but one complex exhibited a turn-on emission response in the presence of amyloid fibrils prepared from hen egg-white lysozyme. The emission response is attributed to hydrophobically-driven binding of the complex to the fibril surface that results in inhibition of azobenzene photoisomerization.
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Two new cyclometalated platinum(II) acetylacetone (acac) complexes have been prepared and characterized. Each complex features a 2-phenylpyridine (ppy) cyclometalating ligand substituted with a peripheral photoswitchable azobenzene group. Azobenzene trans to cis photoisomerization and thermally-induced cis to trans back-isomerization were examined using UV–visible and 1H NMR spectroscopy. Solutions of both complexes were found to be non-luminescent when irradiated at 410 nm in various solvents of differing polarity. A turn-on emission response was observed, however, when the complex possessing a ppy ligand functionalized with an azobenzene unit via an amide linkage was treated with amyloid fibrils prepared from denaturation of hen egg-white lysozyme (HEWL). The emission response is ascribed to steric inhibition of azobenzene photoisomerization upon interaction of the complex with hydrophobic surfaces of HEWL fibrils. X-ray crystal structures of four new Pt(II) complexes are reported as well.
Details
- Title: Subtitle
- Investigation of azobenzene-functionalized (2-phenylpyridine)Pt(II) complexes as switchable luminescent probes for amyloid fibrils
- Creators
- Zhuoheng LiF. Christopher Pigge
- Resource Type
- Journal article
- Publication Details
- Polyhedron, Vol.269, 117394
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.poly.2025.117394
- ISSN
- 0277-5387
- eISSN
- 1873-3719
- Language
- English
- Date published
- 03/01/2025
- Academic Unit
- Radiology; Chemistry
- Record Identifier
- 9984775268502771
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