Journal article
Investigation of gene-environment interactions in relation to tic severity
Journal of neural transmission (Vienna, Austria : 1996), Vol.128(11), pp.1757-1765
11/2021
DOI: 10.1007/s00702-021-02396-y
PMCID: PMC8536549
PMID: 34389898
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
Details
- Title: Subtitle
- Investigation of gene-environment interactions in relation to tic severity
- Creators
- Mohamed Abdulkadir - University Medical Center GroningenDongmei Yu - Massachusetts General HospitalLisa Osiecki - Massachusetts General HospitalRobert A King - Yale UniversityThomas V Fernandez - Yale UniversityLawrence W Brown - Children's Hospital of PhiladelphiaKeun-Ah Cheon - Gangnam Severance HospitalBarbara J Coffey - Icahn School of Medicine at Mount SinaiBlanca Garcia-Delgar - Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.Donald L Gilbert - Cincinnati Children's Hospital Medical CenterDorothy E Grice - Icahn School of Medicine at Mount SinaiJulie Hagstrøm - Mental Health ServicesTammy Hedderly - Kings Health PartnersIsobel Heyman - UCL Institute of Child HealthHyun Ju Hong - Hallym University Sacred Heart HospitalChaim Huyser - De BasculeLaura Ibanez-Gomez - Lutheran Family Health CentersYoung Key Kim - Yonsei UniversityYoung-Shin Kim - University of California San Francisco Medical CenterYun-Joo KohSodahm Kook - Yonsei UniversitySamuel Kuperman - University of IowaBennett Leventhal - University of California San Francisco Medical CenterMarcos Madruga-Garrido - Hospital Universitario Virgen del RocíoAthanasios Maras - YuliusPablo Mir - Hospital Universitario Virgen del RocíoAstrid Morer - Universitat de BarcelonaAlexander Münchau - University of LübeckKerstin J Plessen - Mental Health ServicesVeit Roessner - Technische Universität DresdenEun-Young Shin - Gangnam Severance HospitalDong-Ho Song - Yonsei UniversityJungeun Song - National Health Insurance ServiceFrank Visscher - Admiraal De Ruyter ZiekenhuisSamuel H Zinner - University of WashingtonCarol A Mathews - University of FloridaJeremiah M Scharf - Massachusetts General HospitalJay A Tischfield - Rutgers, The State University of New JerseyGary A Heiman - Rutgers, The State University of New JerseyAndrea Dietrich - University Medical Center GroningenPieter J Hoekstra - University Medical Center Groningen
- Resource Type
- Journal article
- Publication Details
- Journal of neural transmission (Vienna, Austria : 1996), Vol.128(11), pp.1757-1765
- DOI
- 10.1007/s00702-021-02396-y
- PMID
- 34389898
- PMCID
- PMC8536549
- NLM abbreviation
- J Neural Transm (Vienna)
- ISSN
- 0300-9564
- eISSN
- 1435-1463
- Grant note
- K08 MH099424 / NIMH NIH HHS R01 ES021462 / NIEHS NIH HHS R01 MH092293 / NIMH NIH HHS R01 MH079488 / NIMH NIH HHS R01 NS016648 / NINDS NIH HHS R01 MH115963 / NIMH NIH HHS R01 MH092513 / NIMH NIH HHS R01 MH092290 / NIMH NIH HHS R01 MH092291 / NIMH NIH HHS R01 MH092520 / NIMH NIH HHS U24 MH068457 / NIMH NIH HHS R01 MH092516 / NIMH NIH HHS R01 MH079494 / NIMH NIH HHS R01 MH071507 / NIMH NIH HHS U01 NS040024 / NINDS NIH HHS R01 MH092289 / NIMH NIH HHS R01 MH115958 / NIMH NIH HHS R01 MH079489 / NIMH NIH HHS UL1 TR001863 / NCATS NIH HHS R01 MH092292 / NIMH NIH HHS R01 NS040024 / NINDS NIH HHS R13 MH073250 / NIMH NIH HHS R01 MH079487 / NIMH NIH HHS
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293654702771
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