Investigation of probabilistic optimization for tomotherapy

Michael W Kissick; Thomas R Mackie; Ryan T Flynn; Xiaohu Mo; David D Campos; Yue Yan; Donghui Zhao

doi:10.1120/jacmp.v13i5.3865

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Investigation of probabilistic optimization for tomotherapy

Journal article

Open access

Peer reviewed

Investigation of probabilistic optimization for tomotherapy

Michael W Kissick, Thomas R Mackie, Ryan T Flynn, Xiaohu Mo, David D Campos, Yue Yan and Donghui Zhao

Journal of applied clinical medical physics, Vol.13(5), pp.3865-3865

09/2012

DOI: 10.1120/jacmp.v13i5.3865

PMCID: PMC3753820

PMID: 22955654

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https://doi.org/10.1120/jacmp.v13i5.3865View

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Abstract

This work builds on a suite of studies related to the ‘interplay’, or lack thereof, for respiratory motion with helical tomotherapy (HT). It helps explain why HT treatments without active motion management had clinical outcomes that matched positive expectations. An analytical calculation is performed to illuminate the frequency range for which interplay-type dose errors could occur. Then, an experiment is performed which completes a suite of tests. The experiment shows the potential for a stable motion probability distribution function (PDF) with HT and respiratory motion. This PDF enables one to use a motion-robust or probabilistic optimization to intrinsically include respiratory motion into the treatment planning. The reason why HT is robust to respiratory motion is related to the beam modulation sampling of the tumor motion. Because active tracking-based motion management is more complicated for a variety of reasons, HT optimization that is robust to motion is a useful alternative for those many patients that cannot benefit from active motion management.

tumor motion

interplay

IMRT

robust optimization

Details

Title: Subtitle: Investigation of probabilistic optimization for tomotherapy
Creators: Michael W Kissick - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
Thomas R Mackie - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
Ryan T Flynn - Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, IA
Xiaohu Mo - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
David D Campos - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
Yue Yan - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
Donghui Zhao - Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin – Madison, Madison, WI
Resource Type: Journal article
Publication Details: Journal of applied clinical medical physics, Vol.13(5), pp.3865-3865
DOI: 10.1120/jacmp.v13i5.3865
PMID: 22955654
PMCID: PMC3753820
NLM abbreviation: J Appl Clin Med Phys
ISSN: 1526-9914
eISSN: 1526-9914
Grant note: K25 CA119344 || CA / National Cancer Institute : NCI
Language: English
Date published: 09/2012
Academic Unit: Radiation Oncology
Record Identifier: 9984047732902771

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