Journal article
Investigations on the physiological controls of water and saline intake in C57BL/6 mice
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.285(2), pp.R394-R403
08/2003
DOI: 10.1152/ajpregu.00130.2003
PMID: 12714354
Abstract
To examine the behavioral and neural control of body fluid homeostasis, water and saline intake of C57BL/6 mice was monitored under ad libitum conditions, after treatments that induce water or salt intake, and after ablation of the periventricular tissue of the anteroventral third ventricle (AV3V). Mice have nocturnal drinking that is most prevalent after the offset and before the onset of lights. When given ad libitum choice, C57BL/6 mice show no preference for saline over water at concentrations up to 0.9% NaCl and a progressive aversion to saline above that concentration. Systemic hypertonic saline, isoproterenol, and polyethylene glycol treatments are dipsogenic; however, systemic ANG II is not. Intracerebroventricular injections of both hypertonic saline and ANG II are dipsogenic, and diuretic treatment followed by a short period of sodium deprivation induces salt intake. After ablation of the AV3V, mice can be nursed to recovery from initial adipsia and, similar to rats, show chronic deficits to dipsogenic treatments. Taken together, the data indicate that mechanisms controlling thirst in response to cellular dehydration in C57BL/6 mice are similar to rats, but there are differences in the efficacy of extracellular dehydration-related mechanisms, especially for systemic ANG II, controlling thirst and salt appetite.
Details
- Title: Subtitle
- Investigations on the physiological controls of water and saline intake in C57BL/6 mice
- Creators
- Ralph F Johnson - Departments of Psychology and Pharmacology, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Terry G Beltz - Departments of Psychology and Pharmacology, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Robert L Thunhorst - Departments of Psychology and Pharmacology, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242Alan Kim Johnson - Departments of Psychology and Pharmacology, and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.285(2), pp.R394-R403
- DOI
- 10.1152/ajpregu.00130.2003
- PMID
- 12714354
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 08/2003
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213420402771
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