In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model

Edgar A Samaniego; Colin P Derdeyn; Minako Hayakawa; David Hasan; Santiago Ortega-Gutierrez

doi:10.1177/1591019918784915

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In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model

Journal article

Open access

Peer reviewed

In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model

Edgar A Samaniego, Colin P Derdeyn, Minako Hayakawa, David Hasan and Santiago Ortega-Gutierrez

Interventional neuroradiology, Vol.24(6), pp.706-712

12/2018

DOI: 10.1177/1591019918784915

PMCID: PMC6259347

PMID: 29973081

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Abstract

Few liquid embolic materials are available for treatment of arteriovenous malformations. We describe the in vivo experience with the new PHIL low viscosity (LV) liquid embolic agent in a swine rete mirabile model. Eight swine were treated. Two animals underwent embolization of a rete with PHIL LV and the contralateral rete with Squid 12 (euthanized the same day). Six animals underwent embolization of the right rete: two with balloon flow arrest (euthanized at 14 d) and four with a microcatheter alone (euthanized at 14 and 90 d). Performance characteristics of the embolic agents were evaluated. Microscopic and histological analysis of the harvested retia was performed. Macroscopic examinations and high contrast digital-based radiographs of the central nervous system were obtained. We did not experience any technical complication during embolization of each rete. Overall occlusion ability, on/off injection and ease to retrieve the microcatheter/balloon with PHIL LV were optimal. Fluoroscopic visualization of the PHIL LV cast was adequate to optimal. Average embolization time with flow arrest was 9.5 min versus 19.5 min with microcatheter plugging. Embolizations with PHIL LV required less volume and were shorter when compared to Squid 12. Subacute (14 d) and chronic (90 d) microscopic and histological analysis demonstrated minimal inflammatory changes in the perivascular tissues and permanent occlusion of the embolized vasculature. In this swine rete model, the new PHIL LV embolic agent had an excellent embolization performance. Vessels embolized remained occluded up to 90 d from the procedure with minimal inflammatory changes.

Viscosity

Animals

Cerebral Angiography

Swine

Polyvinyls - therapeutic use

Treatment Outcome

Cerebrovascular Circulation

Fluoroscopy

Embolization, Therapeutic - methods

Details

Title: Subtitle: In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model
Creators: Edgar A Samaniego - 3 Department of Neurosurgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Colin P Derdeyn - 2 Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Minako Hayakawa - 2 Department of Radiology, University of Iowa Hospital and Clinics, Iowa City, IA, USA
David Hasan - 3 Department of Neurosurgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Santiago Ortega-Gutierrez - 3 Department of Neurosurgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Interventional neuroradiology, Vol.24(6), pp.706-712
DOI: 10.1177/1591019918784915
PMID: 29973081
PMCID: PMC6259347
NLM abbreviation: Interv Neuroradiol
ISSN: 1591-0199
eISSN: 2385-2011
Publisher: United States
Language: English
Date published: 12/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020616502771

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