Involvement of GDNF and its receptors in the maturation of the periodontal ruffini endings

Yasushi IGARASHI; Megumi AITA; Akiko SUZUKI; Tharanga NANDASENA; Yoshiro KAWANO; Kayoko NOZAWA-INOUE; Takeyasu MAEDA

doi:10.1016/j.neulet.2006.11.012

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Involvement of GDNF and its receptors in the maturation of the periodontal ruffini endings

Journal article

Peer reviewed

Involvement of GDNF and its receptors in the maturation of the periodontal ruffini endings

Yasushi IGARASHI, Megumi AITA, Akiko SUZUKI, Tharanga NANDASENA, Yoshiro KAWANO, Kayoko NOZAWA-INOUE and Takeyasu MAEDA

Neuroscience letters, Vol.412(3), pp.222-226

2007

DOI: 10.1016/j.neulet.2006.11.012

PMID: 17178438

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Abstract

Our recent study revealed an intense immunoreaction for GDNF and its receptors in the Ruffini endings, primary mechanoreceptors in the periodontal ligament, of young rats. However, no information is available for the expression of GDNF and its receptors during their development. The present study aimed to reveal postnatal changes in the immuno-expression of GDNF, GFRalpha1 and RET in the periodontal Ruffini endings of the rat incisors by double immunofluorescent staining. At postnatal day 3 (PO 3d), no structure with GDNF-, GFRalpha1-, or RET-immunoreaction existed in the periodontal ligament. The PGP 9.5-positive nerve fibers without GDNF- and RET-immunoreaction displayed a dendritic fashion at PO 1w, with a GFRalpha1-reaction found around these nerves. At PO 2w, GDNF-positive terminal Schwann cells occurred near the thick and dendritic axons, a part of which showed a RET-reaction, with no reactive cells near the thin nerves. The terminal Schwann cells became positive for GFRalpha1, but lacked RET-immunoreaction. At PO 3w, when the formation of the periodontal Ruffini endings had proceeded, GDNF-positive terminal Schwann cells began to increase in number. This stage-specific immuno-expression pattern suggests that GDNF is a key molecule for the maturation and maintenance of the periodontal Ruffini endings.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Details

Title: Subtitle: Involvement of GDNF and its receptors in the maturation of the periodontal ruffini endings
Creators: Yasushi IGARASHI - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Megumi AITA - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Akiko SUZUKI - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Tharanga NANDASENA - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Yoshiro KAWANO - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Kayoko NOZAWA-INOUE - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Takeyasu MAEDA - Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
Resource Type: Journal article
Publication Details: Neuroscience letters, Vol.412(3), pp.222-226
Publisher: Elsevier; Shannon
DOI: 10.1016/j.neulet.2006.11.012
PMID: 17178438
ISSN: 0304-3940
eISSN: 1872-7972
Language: English
Date published: 2007
Academic Unit: Periodontics
Record Identifier: 9984066098102771

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