Journal article
Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer
Advances in experimental medicine and biology, Vol.937, pp.19-51
2016
DOI: 10.1007/978-3-319-42059-2_2
PMID: 27573893
Abstract
Colorectal cancer (CRC) is one of the most common diagnosed cancers worldwide. The metastasis and development of resistance to anti-cancer treatment are major challenges in the treatment of CRC. Understanding mechanisms underpinning the pathogenesis is therefore critical in developing novel agents for CRC treatments. A large number of evidence has demonstrated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs have functional roles in both the physiological and pathological processes by regulating the expression of their target genes. These molecules are engaged in the pathobiology of neoplastic diseases and are targets for the diagnosis, prognosis and therapy of a variety of cancers, including CRC. In this regard, ncRNAs have emerged as one of the hallmarks of CRC pathogenesis and they also play key roles in metastasis, drug resistance and the stemness of CRC stem cell by regulating various signaling networks. Therefore, a better understanding the ncRNAs involved in the signaling pathways of CRC may lead to the development of novel strategy for diagnosis, prognosis and treatment of CRC. In this chapter, we summarize the latest findings on ncRNAs, with a focus on miRNAs and lncRNAs involving in signaling networks and in the regulation of pathogenic signaling pathways in CRC.
Details
- Title: Subtitle
- Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer
- Creators
- Yinxue Yang - The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, ChinaYong Du - The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, ChinaXiaoming Liu - The General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, ChinaWilliam C Cho - Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China. chocs@ha.org.hk
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.937, pp.19-51
- Publisher
- United States
- DOI
- 10.1007/978-3-319-42059-2_2
- PMID
- 27573893
- eISBN
- 3319420593; 9783319420592
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 2016
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025411802771
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