Journal article
Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats
Hypertension (Dallas, Tex. 1979), Vol.38(4), pp.902-906
Workshop on Structure and Function on Large Arteries
2001
DOI: 10.1161/hy1001.091781
PMID: 11641306
Abstract
We recently showed that brain mineralocorticoid receptors (MRs) are involved in blood pressure and kidney function control in normotensive Wistar rats. We now assessed the involvement of brain MRs in spontaneously hypertensive rats (SHR), in which the presence of adrenocorticoids has been shown to be required for the development of hypertension. The effect of a single intracerebroventricular (ICV) injection of an MR antagonist (RU28318) on systolic blood pressure (SBP) and renal function was examined in conscious adult SHR and Wistar-Kyoto rats (WKY) maintained on a standard-sodium diet (0.4% Na+). In WKY, a long-lasting decrease in SBP was caused by the ICV injection of 10 ng RU28318 as previously reported in Wistar rats, associated with increased urinary excretion of water and electrolytes. In SHR maintained on the standard diet, the ICV injection of RU28318 (10 or 100 ng) had no effect on cardiovascular and renal functions. However, the ICV injection of 10 ng RU28318 in SHR after 3 weeks of high sodium intake (8% Na+) caused a long-lasting decrease in SBP. The effect was present at 8 hours (ΔSBP 34±2 mm Hg), persisted at 24 hours (ΔSBP 29±1 mm Hg), and disappeared at 48 hours after the injection. The hypotension was not associated with changes in heart rate, urinary excretion of water and electrolytes, and plasma renin activity, whereas renal denervation did not affect the decrease in SBP. A more pronounced decrease in SBP (49±3 mm Hg at 8 hours) was observed with 100 ng RU28318. This dose of the antagonist was without effect after subcutaneous administration. Thus, brain MRs appear to participate in the maintenance of hypertension in conscious adult SHR sensitized by sodium loading.
Details
- Title: Subtitle
- Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats
- Creators
- Kamal RAHMOUNI - Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, FranceMariette BARTHELMEBS - Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, FranceMichèle GRIMA - Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, FranceJean-Louis IMBS - Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, FranceWybren DE JONG - Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.38(4), pp.902-906
- Conference
- Workshop on Structure and Function on Large Arteries
- Publisher
- Lippincott; Philadelphia, PA; Hagerstown, MD
- DOI
- 10.1161/hy1001.091781
- PMID
- 11641306
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 2001
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040206302771
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