Journal article
Involvement of the cerebellum in migraine
Frontiers in systems neuroscience, Vol.16, 984406
10/01/2022
DOI: 10.3389/fnsys.2022.984406
PMCID: PMC9608746
PMID: 36313527
Abstract
Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.
Details
- Title: Subtitle
- Involvement of the cerebellum in migraine
- Creators
- Mengya Wang - University of IowaJoseph O. Tutt - Department of Biology and Biochemistry, University of Bath, Bath, United KingdomNicholas O. Dorricott - Department of Biology and Biochemistry, University of Bath, Bath, United KingdomKrystal L. Parker - University of IowaAndrew F. Russo - University of IowaLevi P. Sowers - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in systems neuroscience, Vol.16, 984406
- DOI
- 10.3389/fnsys.2022.984406
- PMID
- 36313527
- PMCID
- PMC9608746
- NLM abbreviation
- Front Syst Neurosci
- ISSN
- 1662-5137
- eISSN
- 1662-5137
- Publisher
- Frontiers Media S.A
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Neurology (Pediatrics)
- Record Identifier
- 9984305370902771
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