Journal article
Inward-rectifying potassium channelopathies: new insights into disorders of sodium and potassium homeostasis
Pediatric nephrology (Berlin, West), Vol.30(3), pp.373-383
03/01/2015
DOI: 10.1007/s00467-014-2764-0
PMID: 24899236
Abstract
Inward-rectifying potassium (Kir) channels allow more inward than outward potassium flux when channels are open in mammalian cells. At physiological resting membrane potentials, however, they predominantly mediate outward potassium flux and play important roles in regulating the resting membrane potential in diverse cell types and potassium secretion in the kidneys. Mutations of Kir channels cause human hereditary diseases collectively called Kir channelopathies, many of which are characterized by disorders of sodium and potassium homeostasis. Studies on these genetic Kir channelopathies have shed light on novel pathophysiological mechanisms, including renal sodium and potassium handling, potassium shifting in skeletal muscles, and aldosterone production in the adrenal glands. Here, we review several recent advances in Kir channels and their clinical implications in sodium and potassium homeostasis.
Details
- Title: Subtitle
- Inward-rectifying potassium channelopathies: new insights into disorders of sodium and potassium homeostasis
- Creators
- Chih-Jen Cheng - Tri-Service General HospitalChih-Chien Sung - Tri-Service General HospitalChou-Long Huang - The University of Texas Southwestern Medical CenterShih-Hua Lin - National Defense Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.30(3), pp.373-383
- Publisher
- Springer Nature
- DOI
- 10.1007/s00467-014-2764-0
- PMID
- 24899236
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Number of pages
- 11
- Grant note
- NSC102-2314-B-016-001; NHRI-EX103-10323SC / NHRI of Taiwan NSC; Ministry of Science and Technology, Taiwan
- Language
- English
- Date published
- 03/01/2015
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359586502771
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