Journal article
Iodine-123 Metaiodobenzylguanidine Cardiac Imaging as a Method to Detect Early Sympathetic Neuronal Dysfunction in Chagasic Patients With Normal or Borderline Electrocardiogram and Preserved Ventricular Function
Clinical nuclear medicine, Vol.36(9), pp.757-761
09/01/2011
DOI: 10.1097/RLU.0b013e31821772a9
PMID: 21825843
Abstract
Purpose: The indeterminate form of Chagas disease represents the most common chronic presentation. The aim of this study was to assess cardiovascular autonomic system function with I-123 metaiodobenzylguanidine (MIBG) scintigraphy in chagasic patients with normal or "borderline" electrocardiographic alterations and preserved left ventricular function evaluated by echocardiography.
Materials and Methods: A total of 40 chagasic patients and 19 control subjects were included in this study. Patients had normal echocardiogram and chest radiography; no arrhythmias or myocardial ischemia; and normal exercise performance for age, gender, and body mass index. I-123 MIBG scintigraphy was performed and the heart-to-mediastinum (H/M) uptake was used as the primary predictor in the present analysis. The data analysis was performed by using Nonparametric Regression Trees and the Survival Agreement Plot. We included only patients with preserved right and left ventricular function assessed by echocardiographic methods.
Results: Variables analyzed in the regression tree were age, sex, 20 minutes and 3 hours H/M uptake after injection of I-123 MIBG, washout rate, and single photon emission computed tomography imaging. The 3 hours H/M ratio was the only significant variable (P < 0.001) and for 95% of chagasic patients, this value was less than 2.19.
Conclusions: This study presents evidence that cardiac autonomic sympathetic modulation may be affected in chagasic subjects with preserved ventricular function evaluated by echocardiography, especially in those with "borderline" electrocardiogram.
Details
- Title: Subtitle
- Iodine-123 Metaiodobenzylguanidine Cardiac Imaging as a Method to Detect Early Sympathetic Neuronal Dysfunction in Chagasic Patients With Normal or Borderline Electrocardiogram and Preserved Ventricular Function
- Creators
- Maria Carolina P. Landesmann - Hospital Samaritano de São PauloLea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21949913 Rio De Janeiro, BrazilBasilio de B. Pereira - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21949913 Rio De Janeiro, BrazilEmilia M. do Nascimento - Univ Fed Rio de Janeiro, Programa Engn Prod, COPPE, BR-21949913 Rio De Janeiro, BrazilPaulo Henrique Rosado-de-Castro - Universidade Federal do Rio de JaneiroSergio Augusto Lopes de Souza - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21949913 Rio De Janeiro, BrazilRonaldo de S. L. Lima - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21949913 Rio De Janeiro, BrazilRoberto C. Pedrosa - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Clinical nuclear medicine, Vol.36(9), pp.757-761
- DOI
- 10.1097/RLU.0b013e31821772a9
- PMID
- 21825843
- NLM abbreviation
- Clin Nucl Med
- ISSN
- 0363-9762
- eISSN
- 1536-0229
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- Coordination for the Improvement of Higher Level Personnel (CAPES-Brazil); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Language
- English
- Date published
- 09/01/2011
- Academic Unit
- Radiology
- Record Identifier
- 9985143124702771
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